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Malignant tumor cells go through morphological and gene expression alterations, including rearrangement of cytoskeleton proteins that promote invasion and metastasis. Microtubules form a major cytoskeleton component that plays a significant role in regulating multiple cellular activities and function depending on the presence of posttranslational modification (PTM). Acetylation is a type of PTM that generally occurs in the lysine 40 region of α‐tubulin and is known to be critically associated with cancer metastasis. Current evidence demonstrates that noncoding RNAs, such as long noncoding RNA (lncRNA) and microRNA (or miRNA), which are correlated with gene regulation modulate the expression of acetylated tubulin in the development and metastasis of cancer. This review provides an overview about the role of lncRNA and miRNA in regulation of tubulin acetylation in various types of cancer. Significance statement: Tubulin acetylation is one of the primary factors contributing to cancer progression and metastasis. It is commonly observed in various cancers like breast cancer, lung cancer, nasopharyngeal carcinoma, and pancreatic cancer. Through the different courses of cancer development, lncRNA and microRNA regulate the expression of this tubulin acetylation. In spite of a number of research studies reporting relationships of various lncRNAs and microRNAs with Tubulin acetylation, a comprehensive review highlighting their interrelationship has yet not been discussed. Understanding their association in depth will be beneficial in developing new treatments for cancer patients. [ABSTRACT FROM AUTHOR]