1. Molecular glues and induced proximity: An evolution of tools and discovery.
- Author
-
Robinson SA, Co JA, and Banik SM
- Subjects
- Humans, Proteins metabolism, Proteins chemistry, Proteins antagonists & inhibitors, Small Molecule Libraries chemistry, Small Molecule Libraries pharmacology, Drug Discovery
- Abstract
Small molecule molecular glues can nucleate protein complexes and rewire interactomes. Molecular glues are widely used as probes for understanding functional proximity at a systems level, and the potential to instigate event-driven pharmacology has motivated their application as therapeutics. Despite advantages such as cell permeability and the potential for low off-target activity, glues are still rare when compared to canonical inhibitors in therapeutic development. Their often simple structure and specific ability to reshape protein-protein interactions pose several challenges for widespread, designer applications. Molecular glue discovery and design campaigns can find inspiration from the fields of synthetic biology and biophysics to mine chemical libraries for glue-like molecules., Competing Interests: Declaration of interests The authors declare no competing interests., (Copyright © 2024 Elsevier Ltd. All rights reserved.)
- Published
- 2024
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