1. Airway Microbiota Dynamics Uncover a Critical Window for Interplay of Pathogenic Bacteria and Allergy in Childhood Respiratory Disease
- Author
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Stephen C. Watts, Robert F. Lemanske, Shu Mei Teo, Kathryn E. Holt, Howard H.F. Tang, Merci M.H. Kusel, Peter D. Sly, Patrick G. Holt, Louise M. Judd, Danny Mok, Yury A. Bochkov, Michael Serralha, Kym Pham, Michael Inouye, Barbara J. Holt, Kristine Grindle, Sebastian L. Johnston, Niamh M. Troy, James E. Gern, Asthma UK, Tang, Howard [0000-0001-6422-0270], Inouye, Michael [0000-0001-9413-6520], and Apollo - University of Cambridge Repository
- Subjects
Male ,0301 basic medicine ,Allergy ,Immunology ,allergic sensitization ,Disease ,Biology ,medicine.disease_cause ,Microbiology ,Cohort Studies ,Allergic sensitization ,03 medical and health sciences ,Risk Factors ,1108 Medical Microbiology ,Nasopharynx ,Virology ,Wheeze ,Hypersensitivity ,medicine ,Humans ,Longitudinal Studies ,Prospective Studies ,Microbiome ,Respiratory Tract Infections ,Respiratory Sounds ,Asthma ,Respiratory tract infections ,Microbiota ,Infant ,Pathogenic bacteria ,Immunoglobulin E ,asthma ,medicine.disease ,airway microbiota ,lower respiratory infection ,030104 developmental biology ,Child, Preschool ,Acute Disease ,Female ,Parasitology ,Disease Susceptibility ,medicine.symptom ,0605 Microbiology - Abstract
Repeated cycles of infection-associated lower airway inflammation drive the pathogenesis of persistent wheezing disease in children. In this study, the occurrence of acute respiratory tract illnesses (ARIs) and the nasopharyngeal microbiome (NPM) were characterized in 244 infants through their first five years of life. Through this analysis, we demonstrate that >80% of infectious events involve viral pathogens, but are accompanied by a shift in the NPM toward dominance by a small range of pathogenic bacterial genera. Unexpectedly, this change frequently precedes the detection of viral pathogens and acute symptoms. Colonization of illness-associated bacteria coupled with early allergic sensitization is associated with persistent wheeze in school-aged children, which is the hallmark of the asthma phenotype. In contrast, these bacterial genera are associated with "transient wheeze" that resolves after age 3 years in non-sensitized children. Thus, to complement early allergic sensitization, monitoring NPM composition may enable early detection and intervention in high-risk children.
- Published
- 2018
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