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Start Over Author "Anna Bostwick" Journal cell reports
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1. Thymidine rescues ATR kinase inhibitor-induced deoxyuridine contamination in genomic DNA, cell death, and interferon-α/β expression

Author

Norie Sugitani, Frank P. Vendetti, Andrew J. Cipriano, Pinakin Pandya, Joshua J. Deppas, Tatiana N. Moiseeva, Sandra Schamus-Haynes, Yiyang Wang, Drake Palmer, Hatice U. Osmanbeyoglu, Anna Bostwick, Nathaniel W. Snyder, Yi-Nan Gong, Katherine M. Aird, Greg M. Delgoffe, Jan H. Beumer, and Christopher J. Bakkenist

Subjects
Cell Death, Nucleotides, Interferon-alpha, Ataxia Telangiectasia Mutated Proteins, DNA, DNA-Directed DNA Polymerase, Genomics, Interferon-beta, CD8-Positive T-Lymphocytes, Deoxyuridine, General Biochemistry, Genetics and Molecular Biology, Mice, Cell Line, Tumor, CDC2 Protein Kinase, Animals, RNA, Protein Kinase Inhibitors, DNA Damage, Thymidine
Abstract

ATR kinase is a central regulator of the DNA damage response (DDR) and cell cycle checkpoints. ATR kinase inhibitors (ATRi's) combine with radiation to generate CD8

Published
2022
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