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8 results on '"Moffat, Jason"'

1. The TSC22D, WNK, and NRBP gene families exhibit functional buffering and evolved with Metazoa for cell volume regulation

Author

Xiao, Yu-Xi, Lee, Seon Yong, Aguilera-Uribe, Magali, Samson, Reuben, Au, Aaron, Khanna, Yukti, Liu, Zetao, Cheng, Ran, Aulakh, Kamaldeep, Wei, Jiarun, Farias, Adrian Granda, Reilly, Taylor, Birkadze, Saba, Habsid, Andrea, Brown, Kevin R., Chan, Katherine, Mero, Patricia, Huang, Jie Qi, Billmann, Maximilian, Rahman, Mahfuzur, Myers, Chad, Andrews, Brenda J., Youn, Ji-Young, Yip, Christopher M., Rotin, Daniela, Derry, W. Brent, Forman-Kay, Julie D., Moses, Alan M., Pritišanac, Iva, Gingras, Anne-Claude, and Moffat, Jason

Published
2024
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3. Characterization of the minimal residual disease state reveals distinct evolutionary trajectories of human glioblastoma

Author

Qazi, Maleeha A., primary, Salim, Sabra K., additional, Brown, Kevin R., additional, Mikolajewicz, Nicholas, additional, Savage, Neil, additional, Han, Hong, additional, Subapanditha, Minomi K., additional, Bakhshinyan, David, additional, Nixon, Allison, additional, Vora, Parvez, additional, Desmond, Kimberly, additional, Chokshi, Chirayu, additional, Singh, Mohini, additional, Khoo, Amanda, additional, Macklin, Andrew, additional, Khan, Shahbaz, additional, Tatari, Nazanin, additional, Winegarden, Neil, additional, Richards, Laura, additional, Pugh, Trevor, additional, Bock, Nicholas, additional, Mansouri, Alireza, additional, Venugopal, Chitra, additional, Kislinger, Thomas, additional, Goyal, Sidhartha, additional, Moffat, Jason, additional, and Singh, Sheila K., additional

Published
2022
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4. The TSC22D, WNK, and NRBPgene families exhibit functional buffering and evolved with Metazoa for cell volume regulation

Author

Xiao, Yu-Xi, Lee, Seon Yong, Aguilera-Uribe, Magali, Samson, Reuben, Au, Aaron, Khanna, Yukti, Liu, Zetao, Cheng, Ran, Aulakh, Kamaldeep, Wei, Jiarun, Farias, Adrian Granda, Reilly, Taylor, Birkadze, Saba, Habsid, Andrea, Brown, Kevin R., Chan, Katherine, Mero, Patricia, Huang, Jie Qi, Billmann, Maximilian, Rahman, Mahfuzur, Myers, Chad, Andrews, Brenda J., Youn, Ji-Young, Yip, Christopher M., Rotin, Daniela, Derry, W. Brent, Forman-Kay, Julie D., Moses, Alan M., Pritišanac, Iva, Gingras, Anne-Claude, and Moffat, Jason

Abstract

The ability to sense and respond to osmotic fluctuations is critical for the maintenance of cellular integrity. We used gene co-essentiality analysis to identify an unappreciated relationship between TSC22D2, WNK1, and NRBP1in regulating cell volume homeostasis. All of these genes have paralogs and are functionally buffered for osmo-sensing and cell volume control. Within seconds of hyperosmotic stress, TSC22D, WNK, and NRBP family members physically associate into biomolecular condensates, a process that is dependent on intrinsically disordered regions (IDRs). A close examination of these protein families across metazoans revealed that TSC22Dgenes evolved alongside a domain in NRBPs that specifically binds to TSC22D proteins, which we have termed NbrT (NRBP binding region with TSC22D), and this co-evolution is accompanied by rapid IDR length expansion in WNK-family kinases. Our study reveals that TSC22D, WNK, and NRBPgenes evolved in metazoans to co-regulate rapid cell volume changes in response to osmolarity.

Published
2024
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5. Essential Gene Profiles for Human Pluripotent Stem Cells Identify Uncharacterized Genes and Substrate Dependencies

Author

Mair, Barbara, primary, Tomic, Jelena, additional, Masud, Sanna N., additional, Tonge, Peter, additional, Weiss, Alexander, additional, Usaj, Matej, additional, Tong, Amy Hin Yan, additional, Kwan, Jamie J., additional, Brown, Kevin R., additional, Titus, Emily, additional, Atkins, Michael, additional, Chan, Katherine S.K., additional, Munsie, Lise, additional, Habsid, Andrea, additional, Han, Hong, additional, Kennedy, Marion, additional, Cohen, Brenda, additional, Keller, Gordon, additional, and Moffat, Jason, additional

Published
2019
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6. The SAGA Deubiquitination Module Promotes DNA Repair and Class Switch Recombination through ATM and DNAPK-Mediated γH2AX Formation

Author

Ramachandran, Shaliny, primary, Haddad, Dania, additional, Li, Conglei, additional, Le, Michael X., additional, Ling, Alexanda K., additional, So, Clare C., additional, Nepal, Rajeev M., additional, Gommerman, Jennifer L., additional, Yu, Kefei, additional, Ketela, Troy, additional, Moffat, Jason, additional, and Martin, Alberto, additional

Published
2016
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7. Genome-wide CRISPR-Cas9 Screens Reveal Loss of Redundancy between PKMYT1 and WEE1 in Glioblastoma Stem-like Cells

Author

Toledo, Chad M., primary, Ding, Yu, additional, Hoellerbauer, Pia, additional, Davis, Ryan J., additional, Basom, Ryan, additional, Girard, Emily J., additional, Lee, Eunjee, additional, Corrin, Philip, additional, Hart, Traver, additional, Bolouri, Hamid, additional, Davison, Jerry, additional, Zhang, Qing, additional, Hardcastle, Justin, additional, Aronow, Bruce J., additional, Plaisier, Christopher L., additional, Baliga, Nitin S., additional, Moffat, Jason, additional, Lin, Qi, additional, Li, Xiao-Nan, additional, Nam, Do-Hyun, additional, Lee, Jeongwu, additional, Pollard, Steven M., additional, Zhu, Jun, additional, Delrow, Jeffery J., additional, Clurman, Bruce E., additional, Olson, James M., additional, and Paddison, Patrick J., additional

Published
2015
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