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4 results on '"Moksa, Michelle"'

1. Autophagy Regulation of Metabolism Is Required for CD8+ T Cell Anti-tumor Immunity

Author

DeVorkin, Lindsay, primary, Pavey, Nils, additional, Carleton, Gillian, additional, Comber, Alexandra, additional, Ho, Cally, additional, Lim, Junghyun, additional, McNamara, Erin, additional, Huang, Haochu, additional, Kim, Paul, additional, Zacharias, Lauren G., additional, Mizushima, Noboru, additional, Saitoh, Tatsuya, additional, Akira, Shizuo, additional, Beckham, Wayne, additional, Lorzadeh, Alireza, additional, Moksa, Michelle, additional, Cao, Qi, additional, Murthy, Aditya, additional, Hirst, Martin, additional, DeBerardinis, Ralph J., additional, and Lum, Julian J., additional

Published
2019
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2. Nucleosome Density ChIP-Seq Identifies Distinct Chromatin Modification Signatures Associated with MNase Accessibility

Author

Lorzadeh, Alireza, primary, Bilenky, Misha, additional, Hammond, Colin, additional, Knapp, David J.H.F., additional, Li, Luolan, additional, Miller, Paul H., additional, Carles, Annaick, additional, Heravi-Moussavi, Alireza, additional, Gakkhar, Sitanshu, additional, Moksa, Michelle, additional, Eaves, Connie J., additional, and Hirst, Martin, additional

Published
2016
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3. Analysis of Normal Human Mammary Epigenomes Reveals Cell-Specific Active Enhancer States and Associated Transcription Factor Networks

Author

Pellacani, Davide, primary, Bilenky, Misha, additional, Kannan, Nagarajan, additional, Heravi-Moussavi, Alireza, additional, Knapp, David J.H.F., additional, Gakkhar, Sitanshu, additional, Moksa, Michelle, additional, Carles, Annaick, additional, Moore, Richard, additional, Mungall, Andrew J., additional, Marra, Marco A., additional, Jones, Steven J.M., additional, Aparicio, Samuel, additional, Hirst, Martin, additional, and Eaves, Connie J., additional

Published
2016
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4. Autophagy Regulation of Metabolism Is Required for CD8 + T Cell Anti-tumor Immunity.

Author

DeVorkin L, Pavey N, Carleton G, Comber A, Ho C, Lim J, McNamara E, Huang H, Kim P, Zacharias LG, Mizushima N, Saitoh T, Akira S, Beckham W, Lorzadeh A, Moksa M, Cao Q, Murthy A, Hirst M, DeBerardinis RJ, and Lum JJ

Subjects
Animals, Autophagy, Humans, Mice, CD8-Positive T-Lymphocytes immunology, Neoplasms immunology
Abstract

Autophagy is a cell survival process essential for the regulation of immune responses to infections. However, the role of T cell autophagy in anti-tumor immunity is less clear. Here, we demonstrate a cell-autonomous role for autophagy in the regulation of CD8 + T-cell-mediated control of tumors. Mice deficient for the essential autophagy genes Atg5, Atg14, or Atg16L1 display a dramatic impairment in the growth of syngeneic tumors. Moreover, T cells lacking Atg5 have a profound shift to an effector memory phenotype and produce greater amounts of interferon-γ (IFN-γ) and tumor necrosis factor α (TNF-α). Mechanistically, Atg5 -/- CD8 + T cells exhibit enhanced glucose metabolism that results in alterations in histone methylation, increases in H3K4me3 density, and transcriptional upregulation of both metabolic and effector target genes. Nonetheless, glucose restriction is sufficient to suppress Atg5-dependent increases in effector function. Thus, autophagy-dependent changes in CD8 + T cell metabolism directly regulate anti-tumor immunity., (Crown Copyright © 2019. Published by Elsevier Inc. All rights reserved.)

Published
2019
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