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1. A neural circuit from the dorsal CA3 to the dorsomedial hypothalamus mediates balance between risk exploration and defense

Author

Cheng Zhong, Lulu Wang, Yi Cao, Chongyang Sun, Jianyu Huang, Xufang Wang, Suwan Pan, Shuyu He, Kang Huang, Zhonghua Lu, Fuqiang Xu, Yi Lu, and Liping Wang

Subjects
Neurons, Mice, Dimenhydrinate, Hypothalamus, Exploratory Behavior, Animals, gamma-Aminobutyric Acid, General Biochemistry, Genetics and Molecular Biology
Abstract

An appropriate balance between explorative and defensive behavior is essential for the survival and reproduction of prey animals in risky environments. However, the neural circuit and mechanism that allow for such a balance remains poorly understood. Here, we use a semi-naturalistic predator threat test (PTT) to observe and quantify the defense-exploration balance, especially risk exploration behavior in mice. During the PTT, the activity of the putative dorsal CA3 glutamatergic neurons (dCA3

Published
2022
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