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Your search keyword '"Wu, Jiaqi"' showing total 3 results
Start Over Author "Wu, Jiaqi" Journal cell reports
3 results on '"Wu, Jiaqi"'

1. Repurposing antiparasitic antimonials to noncovalently rescue temperature-sensitive p53 mutations

Author

Tang, Yigang, primary, Song, Huaxin, additional, Wang, Zhengyuan, additional, Xiao, Shujun, additional, Xiang, Xinrong, additional, Zhan, Huien, additional, Wu, Lili, additional, Wu, Jiale, additional, Xing, Yangfei, additional, Tan, Yun, additional, Liang, Ying, additional, Yan, Ni, additional, Li, Yuntong, additional, Li, Jiabing, additional, Wu, Jiaqi, additional, Zheng, Derun, additional, Jia, Yunchuan, additional, Chen, Zhiming, additional, Li, Yunqi, additional, Zhang, Qianqian, additional, Zhang, Jianming, additional, Zeng, Hui, additional, Tao, Wei, additional, Liu, Feng, additional, Wu, Yu, additional, and Lu, Min, additional

Published
2022
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2. The SARS-CoV-2 Lambda variant exhibits enhanced infectivity and immune resistance

Author

Kimura, Izumi, Kosugi, Yusuke, Wu, Jiaqi, Zahradnik, Jiri, Yamasoba, Daichi, Butlertanaka, Erika P., Tanaka, Yuri L., Uriu, Keiya, Liu, Yafei, Morizako, Nanami, Shirakawa, Kotaro, Kazuma, Yasuhiro, Nomura, Ryosuke, Horisawa, Yoshihito, Tokunaga, Kenzo, Ueno, Takamasa, Takaori-Kondo, Akifumi, Schreiber, Gideon, Arase, Hisashi, The Genotype to Phenotype Japan (G2P-Japan) Consortium, Motozono, Chihiro, Saito, Akatsuki, Nakagawa, So, and Sato, Kei

Subjects
Adult, Male, Lambda, Glycosylation, SARS-CoV-2, Immunity, COVID-19, C.37, Middle Aged, Antibodies, Viral, spike protein, Antibodies, Neutralizing, General Biochemistry, Genetics and Molecular Biology, Cell Line, HEK293 Cells, Report, Mutation, Spike Glycoprotein, Coronavirus, Humans, Female, Aged
Abstract

SARS-CoV-2 Lambda, a variant of interest, has spread in some South American countries; however, its virological features and evolutionary traits remain unknown. In this study, we use pseudoviruses and reveal that the spike protein of the Lambda variant is more infectious than that of other variants due to the T76I and L452Q mutations. The RSYLTPGD246-253N mutation, a unique 7-amino-acid deletion in the N-terminal domain of the Lambda spike protein, is responsible for evasion from neutralizing antibodies and further augments antibody-mediated enhancement of infection. Although this mutation generates a nascent N-linked glycosylation site, the additional N-linked glycan is dispensable for the virological property conferred by this mutation. Since the Lambda variant has dominantly spread according to the increasing frequency of the isolates harboring the RSYLTPGD246-253N mutation, our data suggest that the RSYLTPGD246-253N mutation is closely associated with the substantial spread of the Lambda variant in South America., Graphical Abstract, Kimura et al. reveal the characteristics of SARS-CoV-2 Lambda variant of interest. Lambda spike is more infectious than that of other variants due to the T76I and L452Q mutations. The RSYLTPGD246-253N mutation is responsible for evasion from neutralizing antibodies and further augments antibody-mediated enhancement of infection.

Published
2022

3. Large-scale analysis of 2,152 Ig-seq datasets reveals key features of B cell biology and the antibody repertoire

Author

Yang, Xiujia, primary, Wang, Minhui, additional, Wu, Jiaqi, additional, Shi, Dianchun, additional, Zhang, Yanfang, additional, Zeng, Huikun, additional, Zhu, Yan, additional, Lan, Chunhong, additional, Deng, Yang, additional, Guo, Shixin, additional, Xu, Lijun, additional, Ma, Cuiyu, additional, Zhang, Yanxia, additional, Ou, Jinxia, additional, Liu, Chu-jun, additional, Chen, Yuan, additional, Wang, Qilong, additional, Xie, Wenxi, additional, Guan, Junjie, additional, Ding, Jieyu, additional, Wang, Zhi, additional, Chang, Changqing, additional, Yang, Wei, additional, Zhang, Huijie, additional, Chen, Jun, additional, Qin, Lijie, additional, Zhou, Hongwei, additional, Bei, Jin-Xin, additional, Wei, Lai, additional, Cao, Guangwen, additional, Yu, Xueqing, additional, and Zhang, Zhenhai, additional

Published
2021
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