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Your search keyword '"Aifantis, Iannis"' showing total 9 results
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9 results on '"Aifantis, Iannis"'

1. TRAF6 functions as a tumor suppressor in myeloid malignancies by directly targeting MYC oncogenic activity

Author

Muto, Tomoya, primary, Guillamot, Maria, additional, Yeung, Jennifer, additional, Fang, Jing, additional, Bennett, Joshua, additional, Nadorp, Bettina, additional, Lasry, Audrey, additional, Redondo, Luna Zea, additional, Choi, Kwangmin, additional, Gong, Yixiao, additional, Walker, Callum S., additional, Hueneman, Kathleen, additional, Bolanos, Lyndsey C., additional, Barreyro, Laura, additional, Lee, Lynn H., additional, Greis, Kenneth D., additional, Vasyliev, Nikita, additional, Khodadadi-Jamayran, Alireza, additional, Nudler, Evgeny, additional, Lujambio, Amaia, additional, Lowe, Scott W., additional, Aifantis, Iannis, additional, and Starczynowski, Daniel T., additional

Published
2022
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2. Surface antigen-guided CRISPR screens identify regulators of myeloid leukemia differentiation

Author

Wang, Eric, primary, Zhou, Hua, additional, Nadorp, Bettina, additional, Cayanan, Geraldine, additional, Chen, Xufeng, additional, Yeaton, Anna H., additional, Nomikou, Sofia, additional, Witkowski, Matthew T., additional, Narang, Sonali, additional, Kloetgen, Andreas, additional, Thandapani, Palaniraja, additional, Ravn-Boess, Niklas, additional, Tsirigos, Aristotelis, additional, and Aifantis, Iannis, additional

Published
2021
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4. MED12 Regulates HSC-Specific Enhancers Independently of Mediator Kinase Activity to Control Hematopoiesis

Author

Aranda-Orgilles, Beatriz, primary, Saldaña-Meyer, Ricardo, additional, Wang, Eric, additional, Trompouki, Eirini, additional, Fassl, Anne, additional, Lau, Stephanie, additional, Mullenders, Jasper, additional, Rocha, Pedro P., additional, Raviram, Ramya, additional, Guillamot, María, additional, Sánchez-Díaz, María, additional, Wang, Kun, additional, Kayembe, Clarisse, additional, Zhang, Nan, additional, Amoasii, Leonela, additional, Choudhuri, Avik, additional, Skok, Jane A., additional, Schober, Markus, additional, Reinberg, Danny, additional, Sicinski, Piotr, additional, Schrewe, Heinrich, additional, Tsirigos, Aristotelis, additional, Zon, Leonard I., additional, and Aifantis, Iannis, additional

Published
2016
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5. In Vivo Mapping of Notch Pathway Activity in Normal and Stress Hematopoiesis

Author

Oh, Philmo, primary, Lobry, Camille, additional, Gao, Jie, additional, Tikhonova, Anastasia, additional, Loizou, Evangelia, additional, Manent, Jan, additional, van Handel, Ben, additional, Ibrahim, Sherif, additional, Greve, Jeffrey, additional, Mikkola, Hanna, additional, Artavanis-Tsakonas, Spyros, additional, and Aifantis, Iannis, additional

Published
2013
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6. Regulation of Pluripotency and Cellular Reprogramming by the Ubiquitin-Proteasome System

Author

Buckley, Shannon M., primary, Aranda-Orgilles, Beatriz, additional, Strikoudis, Alexandros, additional, Apostolou, Effie, additional, Loizou, Evangelia, additional, Moran-Crusio, Kelly, additional, Farnsworth, Charles L., additional, Koller, Antonius A., additional, Dasgupta, Ramanuj, additional, Silva, Jeffrey C., additional, Stadtfeld, Matthias, additional, Hochedlinger, Konrad, additional, Chen, Emily I., additional, and Aifantis, Iannis, additional

Published
2012
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8. Hedgehog Signaling Is Dispensable for Adult Hematopoietic Stem Cell Function

Author

Gao, Jie, primary, Graves, Stephanie, additional, Koch, Ute, additional, Liu, Suqing, additional, Jankovic, Vladimir, additional, Buonamici, Silvia, additional, El Andaloussi, Abdeljabar, additional, Nimer, Stephen D., additional, Kee, Barbara L., additional, Taichman, Russell, additional, Radtke, Freddy, additional, and Aifantis, Iannis, additional

Published
2009
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9. Hedgehog Signaling Is Dispensable for Adult Hematopoietic Stem Cell Function.

Author

Jie Gao, Graves, Stephanie, Koch, Ute, Suqing Liu, Jankovic, Vladimir, Buonamici, Silvia, El Andaloussi, Abdeijabar, Nimer, Stephen D., Kee, Barbara L., Traichman, Russell, Radtke, Freddy, and Aifantis, Iannis

Subjects
REGULATION of hematopoiesis, HEMATOPOIETIC growth factors, HEMATOPOIETIC agents, GENETIC models, STEM cells, HEDGEHOG signaling proteins
Abstract

The Hedgehog (Hh) signaling pathway is a developmentally conserved regulator of stem cell function. Several reports suggested that Hh signaling is an important regulator of hematopoietic stem cell (HSC) maintenance and differentiation. Here we test this hypothesis in vivo using both gain- and loss-of-function Hh genetic models. Surprisingly, our studies demonstrate that conditional Smoothened (Smo) deletion or overactivation has no significant effects on adult HSC self-renewal and function. Moreover, they indicate a lack of synergism between the Notch and Hh pathways in HSC function, as compound RBPJ and Smo deficiency does not affect hematopoiesis. In agreement with this notion, detailed genome-wide transcriptome analysis reveals that silencing of Hh signaling does not significantly alter the HSC-specific gene expression "signature." Our studies demonstrate that the Hh signaling pathway is dispensable for adult HSC function and suggest that Hh inhibition on leukemia-initiating cell maintenance can be targeted in future clinical trials. [ABSTRACT FROM AUTHOR]

Published
2009
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