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Your search keyword '"Fox, Ira J."' showing total 12 results
Start Over Author "Fox, Ira J." Journal cell transplantation
12 results on '"Fox, Ira J."'

1. Human Urinary Epithelial Cells as a Source of Engraftable Hepatocyte-Like Cells Using Stem Cell Technology

Author

Sauer, Vanessa, primary, Tchaikovskaya, Tatyana, additional, Wang, Xia, additional, Li, Yanfeng, additional, Zhang, Wei, additional, Tar, Krisztina, additional, Polgar, Zsuzsanna, additional, Ding, Jianqiang, additional, Guha, Chandan, additional, Fox, Ira J., additional, Roy-Chowdhury, Namita, additional, and Roy-Chowdhury, Jayanta, additional

Published
2016
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4. Increased Reprogramming of Human Fetal Hepatocytes Compared with Adult Hepatocytes in Feeder-Free Conditions

Author

Hansel, Marc C., primary, Gramignoli, Roberto, additional, Blake, William, additional, Davila, Julio, additional, Skvorak, Kristen, additional, Dorko, Kenneth, additional, Tahan, Veysel, additional, Lee, Brian R., additional, Tafaleng, Edgar, additional, Guzman-Lepe, Jorge, additional, Soto-Gutierrez, Alejandro, additional, Fox, Ira J., additional, and Strom, Stephen C., additional

Published
2014
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5. Improving the Techniques for Human Hepatocyte Transplantation: Report from a Consensus Meeting in London

Author

Puppi, Juliana, primary, Strom, Stephen C., additional, Hughes, Robin D., additional, Bansal, Sanjay, additional, Castell, Jose V., additional, Dagher, Ibrahim, additional, Ellis, Ewa C. S., additional, Nowak, Greg, additional, Ericzon, Bo-Goran, additional, Fox, Ira J., additional, Gómez-Lechón, M. José, additional, Guha, Chandan, additional, Gupta, Sanjeev, additional, Mitry, Ragai R., additional, Ohashi, Kazuo, additional, Ott, Michael, additional, Reid, Lola M., additional, Roy-Chowdhury, Jayanta, additional, Sokal, Etienne, additional, Weber, Anne, additional, and Dhawan, Anil, additional

Published
2012
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6. Hepatic Differentiation of Mouse iPS Cells in Vitro

Author

Iwamuro, Masaya, primary, Komaki, Toshiyuki, additional, Kubota, Yasuhiro, additional, Seita, Masayuki, additional, Kawamoto, Hironobu, additional, Yuasa, Takeshi, additional, Shahid, Javed M., additional, Hassan, Reham A. R. A., additional, Hassan, Wael A. R. A., additional, Nakaji, Shuhei, additional, Nishikawa, Yuriko, additional, Kondo, Eisaku, additional, Yamamoto, Kazuhide, additional, Fox, Ira J., additional, and Kobayashi, Naoya, additional

Published
2010
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7. Immortalized Hepatocytes Using Human Artificial Chromosome

Author

Ito, Masahiro, primary, Ito, Ryoutaro, additional, Yoshihara, Daisuke, additional, Ikeno, Masashi, additional, Kamiya, Megumi, additional, Suzuki, Nobutaka, additional, Horiguchi, Akihiko, additional, Nagata, Hideo, additional, Yamamoto, Toshiyuki, additional, Kobayashi, Naoya, additional, Fox, Ira J., additional, Okazaki, Tsuneko, additional, and Miyakama, Syuichi, additional

Published
2008
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12. Instant hepatic differentiation of human embryonic stem cells using activin A and a deleted variant of HGF.

Author

Chen Y, Soto-Gutierrez A, Navarro-Alvarez N, Rivas-Carrillo JD, Yamatsuji T, Shirakawa Y, Tanaka N, Basma H, Fox IJ, and Kobayashi N

Subjects
Albumins metabolism, Ammonia metabolism, Cell Line, Dose-Response Relationship, Drug, Embryonic Stem Cells cytology, Embryonic Stem Cells ultrastructure, Glycogen metabolism, Hepatocyte Growth Factor genetics, Hepatocytes drug effects, Hepatocytes metabolism, Hepatocytes ultrastructure, Humans, Lidocaine metabolism, Microscopy, Electron, Transmission, Mutation, Activins pharmacology, Cell Differentiation drug effects, Embryonic Stem Cells drug effects, Hepatocyte Growth Factor pharmacology
Abstract

Human embryonic stem (hES) cells have the ability to differentiate into a variety of different cell lineages and potentially provide a source of differentiated cells for many therapeutic uses. Here we investigated an efficient method of hepatic differentiation from hES cells. A human ES cell line, KhES-1, was used and maintained by a nonfeeder method. KhES-1 cells were cultured for 5 days in the presence of human activin A (50 ng/ml) and then treated with a deleted variant of hepatocyte growth factor (dHGF) at 0, 100, or 500 ng/ml for 7 days. The resultant cells were biologically analyzed. The expression of the endodermal genes SOX17 and FOXA2 increased in KhES-1 cells after activin A treatment. In contrast, Oct4, a self-renewal undifferentiated marker, decreased in a time-dependent manner in KhES-1 cells. Following a 7-day treatment of the resultant cells with dHGF, especially at 500 ng/ml, KhES-1 cells showed an expression of the hepatic makers albumin, AFP, and CK18. Transitional electron microscopy showed well-developed glycogen rosettes and a gap junction in KhES-1 cells treated with 500 ng/ml of dHGF. We developed an efficient method to differentiate KhES-1 cells into hepatocyte-like cells in vitro using 50 ng/ml of activin A and 500 ng/ml of dHGF.

Published
2006
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