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2 results on '"Marco, Sequi"'

1. Impact of Islet Size on Pancreatic Islet Transplantation and Potential Interventions to Improve Outcome

Author

Daria Zorzi, Tammy Phan, Marco Sequi, Yong Lin, Daniel H. Freeman, Luca Cicalese, and Cristiana Rastellini M.D.

Subjects
Medicine
Abstract

Better results have been recently reported in clinical pancreatic islet transplantation (ITX) due mostly to improved isolation techniques and immunosuppression; however, some limitations still exist. It is known that following transplantation, 30% to 60% of the islets are lost. In our study, we have investigated 1) the role of size as a factor affecting islet engraftment and 2) potential procedural manipulations to increase the number of smaller functional islets that can be transplanted. C57/BL10 mice were used as donors and recipients in a syngeneic islet transplant model. Isolated islets were divided by size (large, >300 μm; medium 150–300 μm; small,

Published
2015
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2. Impact of Islet Size on Pancreatic Islet Transplantation and Potential Interventions to Improve Outcome

Author

Cristiana Rastellini, Luca Cicalese, Tammy Phan, Yong Lin, Daniel H. Freeman, Daria Zorzi, and Marco Sequi

Subjects
Male, medicine.medical_specialty, endocrine system, endocrine system diseases, medicine.medical_treatment, Biomedical Engineering, Islets of Langerhans Transplantation, lcsh:Medicine, Article, Diabetes Mellitus, Experimental, Islets of Langerhans, Mice, Internal medicine, Diabetes mellitus, Medicine, Animals, Fragmentation (cell biology), Isolated islets, Transplantation, geography, geography.geographical_feature_category, business.industry, Graft Survival, lcsh:R, Immunosuppression, Diabetic mouse, Cell Biology, Organ Size, Islet, medicine.disease, Transplantation, Isogeneic, Endocrinology, surgical procedures, operative, Pancreatic islet transplantation, business
Abstract

Better results have been recently reported in clinical pancreatic islet transplantation (ITX) due mostly to improved isolation techniques and immunosuppression; however, some limitations still exist. It is known that following transplantation, 30% to 60% of the islets are lost. In our study, we have investigated 1) the role of size as a factor affecting islet engraftment and 2) potential procedural manipulations to increase the number of smaller functional islets that can be transplanted. C57/BL10 mice were used as donors and recipients in a syngeneic islet transplant model. Isolated islets were divided by size (large, >300 μm; medium 150–300 μm; small

Published
2015

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