1. MMP14 in Sarcoma: A Regulator of Tumor Microenvironment Communication in Connective Tissues
- Author
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Zehuan Liao, Päivi M. Ojala, Joseph W. Carlson, Silvia Gramolelli, Jordi Gonzalez-Molina, Kaisa Lehti, and School of Biological Sciences
- Subjects
sarcoma ,OSTEOSARCOMA CELLS ,Review ,Cell Communication ,Matrix (biology) ,Metastasis ,Extracellular matrix ,0302 clinical medicine ,TYPE-1 MATRIX-METALLOPROTEINASE ,Tumor Microenvironment ,Neoplasm Metastasis ,Child ,lcsh:QH301-705.5 ,IN-VIVO ,INTRACELLULAR ACTIVATION ,0303 health sciences ,MMP14 ,mesenchymal phenotype ,Biological sciences [Science] ,Sarcoma ,General Medicine ,EPITHELIAL-MESENCHYMAL TRANSITION ,3. Good health ,Extracellular Matrix ,Gene Expression Regulation, Neoplastic ,Connective Tissue ,030220 oncology & carcinogenesis ,Life Sciences & Biomedicine ,Adult ,Biology ,03 medical and health sciences ,medicine ,EXTRACELLULAR-MATRIX ,Matrix Metalloproteinase 14 ,CELL INVASION ,metastasis ,Humans ,Neoplasm Invasiveness ,Epithelial–mesenchymal transition ,030304 developmental biology ,Tumor microenvironment ,Science & Technology ,MMP-2 ACTIVATION ,Mesenchymal stem cell ,Cell Biology ,medicine.disease ,lcsh:Biology (General) ,Cancer research ,1-MATRIX METALLOPROTEINASE ,MAPK ACTIVATION - Abstract
Sarcomas are deadly malignant tumors of mesenchymal origin occurring at all ages. The expression and function of the membrane-type matrix metalloproteinase MMP14 is closely related to the mesenchymal cell phenotype, and it is highly expressed in most sarcomas. MMP14 regulates the activity of multiple extracellular and plasma membrane proteins, influencing cell–cell and cell–extracellular matrix (ECM) communication. This regulation mediates processes such as ECM degradation and remodeling, cell invasion, and cancer metastasis. Thus, a comprehensive understanding of the biology of MMP14 in sarcomas will shed light on the mechanisms controlling the key processes in these diseases. Here, we provide an overview of the function and regulation of MMP14 and we discuss their relationship with clinical and pre-clinical MMP14 data in both adult and childhood sarcomas. Published version
- Published
- 2019