1. Self-reactive IgG4 antibodies are associated with blocking of pathology in human lymphatic filariasis.
- Author
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Mishra R, Panda SK, Sahoo PK, Mishra S, and Satapathy AK
- Subjects
- Actins genetics, Actins immunology, Adult, Animals, Antibodies, Helminth blood, Antigens, Helminth blood, Antigens, Helminth genetics, Asymptomatic Diseases, Autoantibodies blood, Autoantigens immunology, B-Lymphocytes immunology, B-Lymphocytes parasitology, DNA, Single-Stranded genetics, DNA, Single-Stranded immunology, Elephantiasis, Filarial genetics, Elephantiasis, Filarial parasitology, Elephantiasis, Filarial pathology, Female, Gene Expression, Humans, Immunoglobulin A blood, Immunoglobulin G blood, Male, Middle Aged, Myosins genetics, Myosins immunology, Severity of Illness Index, Wuchereria bancrofti pathogenicity, Antibodies, Helminth genetics, Autoantibodies genetics, Autoantigens genetics, Elephantiasis, Filarial immunology, Immunoglobulin A genetics, Immunoglobulin G genetics, Wuchereria bancrofti immunology
- Abstract
Lymphatic filariasis, a chronic disfiguring disease exhibits complex pathology. Based on different clinical manifestations, infected individuals are categorized into asymptomatic-carriers and chronic-patients. The mechanism behind differential clinical outcomes remains unclear. Roles of filaria-specific B cell responses in filariasis have been documented, whereas the contribution of B1 cell response and poly-specific IgG and IgA in the context of clinical filariasis is not deciphered. In this study, we measured the poly-specific IgG and IgA levels in different clinical categories of filariasis. Asymptomatic-carriers exhibited increased IgG4 antibodies against both filarial-antigens as well as auto-antigens compared to other clinical categories, although IgG against these auto-antigens remained lower. IgA levels against both filarial and auto-antigens were decreased in asymptomatic-carriers. A positive correlation between anti-filarial IgG4 and IgG4 against auto-antigens were observed, suggesting the synergistic role of poly-specific natural IgG4 with anti-filarial IgG4 in blocking the pathogenesis in asymptomatic microfilarial cases., (Copyright © 2019 Elsevier Inc. All rights reserved.)
- Published
- 2019
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