1. High HSP27 and HSP70 expression levels are independent adverse prognostic factors in primary resected colon cancer
- Author
-
Rupert Langer, Ulrich Nitsche, Karina Bauer, Claus Hann von Weyhern, Julia Slotta-Huspenina, Enken Drecoll, Heinz Höfler, and Robert D. Rosenberg
- Subjects
Oncology ,Adult ,Male ,Cancer Research ,medicine.medical_specialty ,animal structures ,Colorectal cancer ,HSP27 Heat-Shock Proteins ,Hsp27 ,Internal medicine ,Heat shock protein ,Medicine ,Humans ,HSP70 Heat-Shock Proteins ,Lymph node ,Pathological ,Heat-Shock Proteins ,Aged ,Aged, 80 and over ,Tissue microarray ,biology ,business.industry ,General Medicine ,Chaperonin 60 ,Middle Aged ,medicine.disease ,Prognosis ,Immunohistochemistry ,Survival Analysis ,digestive system diseases ,medicine.anatomical_structure ,Colonic Neoplasms ,Multivariate Analysis ,biology.protein ,Molecular Medicine ,Biomarker (medicine) ,Female ,business ,Molecular Chaperones - Abstract
The expression of Heat Shock Proteins (HSPs) is increased in various cancers and has been shown to correlate with biological tumor behaviour. This study aimed to investigate the impact of HSP70, HSP60 and HSP27 expression in colon cancer. HSP expression was determined by immunohistochemistry on a tissue microarray with 355 primary resected colon carcinomas of all stages. Expression patterns were correlated with pathologic features (UICC pTNM category, tumor grading) and survival. Expression of HSP27, HSP60 and HSP70 ranged from negative to high. There was no correlation between HSP27, HSP60 and HSP70 expression among each other and with UICC pT category, presence of lymph node or distant metastases or tumor grading. High HSP70 expression was associated with worse overall survival (p
- Published
- 2012