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Start Over Author "David Mears" Journal cellular physiology and biochemistry
2 results on '"David Mears"'

1. Contents Vol. 29, 2012

Author

Yonggang Lu, Michael Reppel, Suozhu Shi, Nikolaus Blin, Louis Ruiz, Patricia R. M. Rocco, Pei Wang, Ting Zhang, Yicun Chen, Yamila V. Carmona Viglianco, Andreas Breß, Fanqin Zeng, Jaime Mas-Oliva, Soraia G. Abreu, Guibo Sun, Mingli Jin, Debora G. Xisto, Silke Haerteis, Carina Lammers, María Antonia Cid, Shefalee K. Bhavsar, Jun Zhang, Wolf-Michael Weber, Xueguang Zhang, Ilsley Colton, Yijin Luo, Tomoyuki Nishizaki, Enrique Jaimovich, Adriana L. Silva, Silvia del Valle Alonso, George Osol, Carlos Facundo Temprana, Verena Jendrossek, Hoo Kyun Choi, Shaoheng He, Zhihua Liu, Mu Li, Maurizio Mandalà, Yanfang Han, Henning Reis, Katja Steinke, Jochen Müller-Ehmsen, Marcelo M. Morales, Nadine Bangel-Ruland, Yvonne Knieper, David Mears, Odile Sergent, Lumian Zhang, Ana Cecilia Anzulovich, Tomo Saric, Xiaoyu Yu, Dan Yang, Nora Riveros, Dennis Rottländer, Xiaoning Zeng, Hitomi Kamiya, Min Cao, Theresa Dartsch, Xavier Tekpli, Lin Dou, Guiscard Seebohm, Ping Xie, Shuwen Liu, Heinrich Sticht, Yu Zheng, Ethel García-Latorre, Tanqi Lou, Kurt Pfannkuche, Zongfang Li, Ying He, María Antonia Martínez, Alicia Ortega, Dagoberto Delgado-Franco, Carlos A. Marra, Ximena Leighton, Daniel Schaal, Quan Hong, Haiwei Yang, Veronica A. Peotta, Ke Li, Carsten Zobel, Xu Zeng, Nathalie Strutz-Seebohm, Dominik Heider, Illani Atwater, Aldo Tirado-Cortes, Jessica Morgner, Guozhen Tan, Mathias C. Brandt, Jude S. Morton, Cui-Cui Li, Geraldine Leier, Xiaobo Sun, Guomin Ren, Tao Shen, Gang Hu, Eduardo Rojas, Miki Honda, Hannes Reuter, Claudine Irles, Stefan Brüschke, Yuansheng Xie, Gianna-Carina Gruen, Xiaoluan Liu, Jinhong Zheng, Jian Li, Charles L. Zimliki, Takeshi Kanno, Limei Zhang, Gonzalo Jorquera, Xiaofeng Le, Xiangmei Chen, Silvana S. Meyrelles, Dominique Lagadic-Gossmann, Jesús Vega-Moreno, Dong-Im Cho, R. Alvarez, Yong Man, Kurt Werner Schmid, Zohreh Hosseinzadeh, Suyun Ji, Ulrike Henrion, Sven Zumhagen, Zhidong Wang, Toni Schneider, Elisardo C. Vasquez, Kyeong-Man Kim, Akinobu Gotoh, Stephan Schwarzinger, Yang Lv, María Ángeles Trillo, Cui Li, Christoph Korbmacher, Magdalena Zak, ZunFu Ke, Ying Pan, Ae-Kyung Yi, Qing Guo, Simon Ockenpoehler, Birgit Stallmeyer, Kristian Schweimer, Marco Weiergraeber, Jørn A. Holme, Dario C. Ramirez, Katja Sobczak, Shu Wang, Rebecca M. Parodi-Rullán, Miguel Palacios-Sánchez, Yuanyuan Ji, Harvey B. Pollard, Meera Srivastava, Xun Liu, Julia Crosseti, Sabrina V. Martini, Hang Liu, Markus Pfister, Gabriel Peinkofer, Felix Brauer, Robert Rauh, Pablo Caviedes, Filomain Nguemo, Johnatas D. Silva, Jinzhi Wang, Shu Zhang, Marie-Thérèse Dimanche-Boitrel, Marlies Knipper, Laurence Huc, Rui Ding, Cheng Wang, José Casasnovas, Peter Ruth, Sandra T. Davidge, Jürgen Hescheler, Uta C. Hoppe, ZengChun Ye, Sandra E. Gomez-Mejiba, Nevenka Juretić, Alejandro Úbeda, Florian Lang, Paul Rösch, María Sofía Giménez, Can-Ming Li, So-Young Kim, Fengjun Wang, Mei Zheng, Xiuqing Huang, Niels Brandt, Mariela J. Coria, Li Zhang, Eric Schulze-Bahr, José Guzmán-Bárcenas, Giselle Barreto-Torres, Béatrice Dendelé, Manfred Watzele, Christoph Franz, Yumiko Fujita, Marcel Halbach, Joel Arias-Martínez, Daniel Kessler, Mirta Glassman, Sabzali Javadov, Takashi Nakano, and Ying Tang

Subjects
Physiology
Published
2012
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2. The Anx7(+/-) Knockout Mutation Alters Electrical and Secretory Responses to Ca2+-Mobilizing Agents in Pancreatic �-cells

Author

Ximena Leighton, Mirta Glassman, David Mears, Meera Srivastava, Harvey B. Pollard, Charles L. Zimliki, Illani Atwater, and Eduardo Rojas

Subjects
medicine.medical_specialty, Carbachol, Physiology, Mutant, Biology, Muscarinic agonist, Membrane Potentials, Islets of Langerhans, Mice, Internal medicine, Insulin Secretion, medicine, Animals, Insulin, Annexin A7, Receptor, Mice, Knockout, Ryanodine receptor, Ryanodine Receptor Calcium Release Channel, Inositol trisphosphate receptor, Glucose, Endocrinology, Mutation, Calcium, Signal transduction, Intracellular, medicine.drug
Abstract

Insulin secretion from the pancreatic β-cell is controlled by changes in membrane potential and intracellular Ca(2+). The contribution of intracellular Ca(2+) stores to this process is poorly understood. We have previously shown that β-cells of mice lacking one copy of the Annexin 7 gene (Anx7(+/-)) express reduced levels of IP(3) receptors and defects in IP(3)-dependent Ca(2+) signaling. To further elucidate the effect of the Anx7(+/-) mutation on signaling related to intracellular Ca(2+) stores in the β-cell, we measured the effects of Ca(2+) mobilizing agents on electrical activity, intracellular Ca(2+) and insulin secretion in control and mutant β-cells. We found that the muscarinic agonist carbachol and the ryanodine receptor agonists caffeine and 4-chloro-m-cresol had more potent depolarizing effects on Anx7(+/-) β-cells compared to controls. Accordingly, glucose-induced insulin secretion was augmented to a greater extent by caffeine in mutant islets. Surprisingly, ryanodine receptor-mediated Ca(2+) mobilization was not affected by the Anx7(+/-) mutation, suggesting that the mechanism underlying the observed differences in electrical and secretory responsiveness does not involve intracellular Ca(2+) stores. Our results provide evidence that both IP3 receptors and ryanodine receptors play important roles in regulating β-cell membrane potential and insulin secretion, and that the Anx7(+/-) mutation is associated with alterations in the signaling pathways related to these receptors.

Published
2012
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