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Your search keyword '"Teresa Bielecka"' showing total 2 results
Start Over Author "Teresa Bielecka" Journal central european journal of immunology
2 results on '"Teresa Bielecka"'

1. Tuberculosis infection in children with proteinuria/nephrotic syndrome

Author

Hanna Szymanik-Grzelak, Elżbieta Kuźma-Mroczkowska, Piotr Skrzypczyk, Teresa Bielecka, Iwona Kotula, and Małgorzata Pańczyk-Tomaszewska

Subjects
children, tuberculosis, proteinuria, nephrotic syndrome, Medicine
Abstract

Children with nephrotic syndrome (NS) are at greater risk of infections than the general population, due to immunodeficiency in the course of the disease and the treatment. In this study we present 4 children (2 girls, 2 boys), mean age 7.6 ±5.1 years, with NS/proteinuria and latent tuberculosis in 3 children and lymph node tuberculosis in 1 child. The reasons for testing these children for tuberculosis (TB) were the evaluation of the epidemiological status before treatment with corticosteroids (GCS), leukopenia and the relapse of NS, and non-nephrotic proteinuria. The diagnosis of TB infection was based on positive IGRA (Interferon-Gamma Release Assay). Chest X-ray was normal in all the children. Chest CT scan revealed an enlargement of lymph nodes in 1 child. The children were treated with isoniazid (3 children) and isoniazid, rifampicin and pyrazinamide (1 child). Three children with idiopathic nephrotic syndrome were treated with prednisone. The child with non-nephrotic proteinuria was treated with enalapril. Proteinuria disappeared in all children during anti-TB treatment.

Published
2017
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2. Molecular methods in diagnostics of post-BCG vaccine adverse events

Author

Sylwia Agata BrzeziŃska, Monika Kozińska, Teresa Bielecka, Agnieszka GŁogowska, Anna Zabost, and Ewa Augustynowicz-Kopeć

Subjects
Tuberculosis, biology, business.industry, Immunology, Mycobacterium tuberculosis, vaccines, medicine.disease, biology.organism_classification, Mycobacterium tuberculosis complex, Multiplex polymerase chain reaction, Genotype, medicine, Immunology and Allergy, Clinical Immunology, Adverse effect, business, Tuberculosis vaccines, BCG vaccine, Bacillus Calmette-Guerin
Abstract

Introduction Bacillus Calmette-Guerin (BCG) is the only tuberculosis vaccine available and although it has been routinely used for more than 80 years, its protective effect varies depending on the age and the form of tuberculosis. Due to the close analogy between the vaccine strain and other species of the Mycobacterium tuberculosis complex, molecular methods are recommended for differential diagnosis of post-BCG complications. The aim of the study was to assess usefulness of molecular methods in diagnosis of post-BCG vaccine adverse events (VAEs). Material and methods M. tuberculosis complex strains obtained in 2011-2017 from 68 ill children were subjected to molecular analysis. Results Molecular analysis of 68 strains showed 100% agreement between the results in the GenoType MTBC method and the multiplex PCR method. For the strains isolated from 45 patients with suspected VAE, M. bovis BCG was obtained, whereas the strains isolated from the remaining 23 children were identified as M. tuberculosis. The analysis confirmed the close relationship between the result of identification and the type of material as well as the patient's age. Conclusions The use of genetic methods enables quick and detailed diagnostics of infections caused by M. bovis BCG, which allows for the confirmation or exclusion of VAE.

Published
2020

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