1. LTDpathies: a Novel Clinical Concept.
- Author
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Mitoma, Hiroshi, Honnorat, Jerome, Yamaguchi, Kazuhiko, and Manto, Mario
- Subjects
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VESTIBULO-ocular reflex , *PURKINJE cells , *NEUROLOGICAL disorders , *LONG-term synaptic depression , *APATHY , *NEURAL circuitry , *SPINOCEREBELLAR ataxia , *ENCEPHALITIS - Abstract
1 Schematic diagram of the pathophysiological mechanisms underlying anti-VGCC, anti-mGluR1, and anti-GluR delta-associated cerebellar ataxias ("LTDpathies"). Basal synaptic transmission is impaired not only by anti-VGCC Abs but also by anti-mGluR1 and GluR delta Abs [[24]]. These studies suggest that anti-VGCC, anti-mGluR1, and anti-GluR delta Abs-associated cerebellar ataxias share one common pathophysiological mechanism, the deregulated PF-PC LTD. In IMCAs, various synaptic proteins, such as glutamic acid decarboxylase 65 (GAD65), voltage-gated Ca channel (VGCC), metabotropic glutamate receptor type 1 (mGluR1), and glutamate receptor delta (GluR delta), are targets of auto-immunity [[14]-[16]]. [Extracted from the article]
- Published
- 2021
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