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Mayerová M, Turjap M, Ustohal L, Pivnička J, Češková E. Therapeutic drug monitoring of olanzapine and clozapine The article summarizes existing basic literature and recommendations concerning therapeutic drug monitoring (TDM) of antipsychotics. It is focused on olanzapine and clozapine. Moreover, the terms "therapeutic drug monitoring" and "therapeutic reference range" are explained and indications for TDM are summarized. The factors that can influence plasma levels and that can be influenced by plasma levels are also mentioned. The article reports, where and how TDM can be done in the Czech Republic. [ABSTRACT FROM AUTHOR]

Quetiapine is atypical antipsychotic with remarkable clinical and receptor-binding profile depending on dosage used. Plasma concentrations and also clinical response vary markedly after equal doses between individuals in clinical practice. Polypharmacy and suboptimal adherence is common. The drug is metabolised by cytochrome P450 and thus, clinically important pharmacokinetic drug-drug interactions are likely. There is evidence from literature about plasma concentrations obtained at therapeutically effective doses. Quetiapine is therefore suitable candidate for therapeutic drug monitoring. Here we present an overview of biotransformation and pharmacokinetic drug-drug interactions and current knowledge on therapeutic drug monitoring of quetiapine, its benefits and limitations. [ABSTRACT FROM AUTHOR]