1. The Multifaceted Inhibitory Effects of an Alkylquinolone on the Diatom Phaeodactylum tricornutum.
- Author
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Dow L, Stock F, Peltekis A, Szamosvári D, Prothiwa M, Lapointe A, Böttcher T, Bailleul B, Vyverman W, Kroth PG, and Lepetit B
- Subjects
- Chloroplasts drug effects, Diatoms growth & development, Mitochondria drug effects, Photosynthesis, 4-Quinolones pharmacology, Adenosine Triphosphate metabolism, Cytochrome b6f Complex antagonists & inhibitors, Diatoms drug effects, Mitochondria physiology, Plastids drug effects, Thylakoids metabolism
- Abstract
The mechanisms underlying interactions between diatoms and bacteria are crucial to understand diatom behaviour and proliferation, and can result in far-reaching ecological consequences. Recently, 2-alkyl-4-quinolones have been isolated from marine bacteria, both of which (the bacterium and isolated chemical) inhibited growth of microalgae, suggesting these compounds could mediate diatom-bacteria interactions. The effects of several quinolones on three diatom species have been investigated. The growth of all three was inhibited, with half-maximal inhibitory concentrations reaching the sub-micromolar range. By using multiple techniques, dual inhibition mechanisms were uncovered for 2-heptyl-4-quinolone (HHQ) in Phaeodactylum tricornutum. Firstly, photosynthetic electron transport was obstructed, primarily through inhibition of the cytochrome b
6 f complex. Secondly, respiration was inhibited, leading to repression of ATP supply to plastids from mitochondria through organelle energy coupling. These data clearly show how HHQ could modulate diatom proliferation in marine environments., (© 2019 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA.)- Published
- 2020
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