1. ALPHA.-Glucosidase Inhibitory Constituents from Duranta repens
- Author
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Naveen Mukhtar, Kiran Iqbal, Shamsun Nahar Khan, Itrat Anis, Abdul Malik, and Muhammad Iqbal Choudhary
- Subjects
biology ,Plant Extracts ,Stereochemistry ,Chemistry ,Verbenaceae ,Duranta ,alpha-Glucosidases ,General Chemistry ,General Medicine ,Nuclear magnetic resonance spectroscopy ,biology.organism_classification ,Repens ,Terpenoid ,Drug Discovery ,Glycoside Hydrolase Inhibitors ,Enzyme Inhibitors ,Plant Structures ,Hardwickiic acid ,α glucosidase inhibitory - Abstract
Three C-alkylated flavonoids 7-O-alpha-D-glucopyranosyl-3,5-dihydroxy-3'-(4"-acetoxyl-3"-methylbutyl)-6,4'-dimethoxyflavone (1), 7-O-alpha-D-glucopyranosyl-3,4'-dihydroxy-3'-(4"-acetoxyl-3"-methylbutyl)-5,6-dimethoxyflavone (2), 3,7,4'-trihydroxy-3'-(8"-acetoxy-7"-methyloctyl)-5,6-dimethoxyflavone (3) and a trans-clerodane type diterpenoid (-)-6beta-hydroxy-5beta,8beta,9beta,10alpha-cleroda-3,13-dien-16,15-olid-18-oic acid (4) are reported from Duranta repens along with (+)-hardwickiic acid (5) and (+)-3,13-clerodadien-16,15-olid-18-oic acid (6), isolated for the first time from this species. Their structures were established on the basis of the spectral methods, especially two dimensional (2D) NMR spectroscopy.
- Published
- 2004
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