1. The effect of chrysin-loaded nanofiber on wound healing process in male rat
- Author
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Abolfazl Akbarzadeh, Meisam Barati, Zoheyr Mohammadi, Ali Mohammad Latifi, Mohsen Sharif Zak, Khaled Seidi, and Hasan Majdi
- Subjects
Male ,Antioxidant ,Polyesters ,medicine.medical_treatment ,Flavonoid ,Nanofibers ,Nitric Oxide Synthase Type II ,macromolecular substances ,Pharmacology ,Matrix metalloproteinase ,Biochemistry ,Polyethylene Glycols ,030207 dermatology & venereal diseases ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,In vivo ,Spectroscopy, Fourier Transform Infrared ,Drug Discovery ,medicine ,Animals ,Chrysin ,Flavonoids ,chemistry.chemical_classification ,Drug Carriers ,Tissue Inhibitor of Metalloproteinase-2 ,Wound Healing ,Tissue Inhibitor of Metalloproteinase-1 ,Chemistry ,Organic Chemistry ,technology, industry, and agriculture ,Rats ,Matrix Metalloproteinase 8 ,Matrix Metalloproteinase 9 ,030220 oncology & carcinogenesis ,Nanofiber ,Microscopy, Electron, Scanning ,Matrix Metalloproteinase 2 ,Molecular Medicine ,Tumor Suppressor Protein p53 ,Drug carrier ,Wound healing - Abstract
Wound healing is an inflammatory process. Chrysin, a natural flavonoid found in honey, has been recently investigated to have anti-inflammatory and antioxidant effects. In this work, the effects of chrysin-loaded nanofiber on the expressions of genes that are related to wound healing process such as P53, TIMPs, MMPs, iNOS, and IL-6 in an animal model study were evaluated. The electrospinning method was used for preparation the different concentrations of chrysin-loaded PCL-PEG nanofiber (5%, 10%, and 20% [w/w]) and characterized by FTIR and SEM. The wound healing effects of chrysin-loaded PCL-PEG nanofiber were in vivo investigated in rats, and the expressions of genes related to wound healing process were evaluated by real-time PCR. The study results showed chrysin-loaded PLC-PEG compared to chrysin ointment and control groups significantly increase IL-6, MMP-2, MMP-8, MMP-9, TIMP-1, and TIMP-2 (p
- Published
- 2017
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