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1. Role of Pd(II)-chitooligosaccharides-Gboxin analog in oxidative phosphorylation inhibition and energy depletion: Targeting mitochondrial dynamics

Author

Ali A. Shati, Hani S. Hafez, Reda F.M. Elshaarawy, Mohammad Y. Alfaifi, Mohammed Alshehri, and Serag Eldin I. Elbehairi

Subjects
Male, ATPase, Oligosaccharides, Antineoplastic Agents, Chitin, Oxidative phosphorylation, 01 natural sciences, Biochemistry, Mitochondrial Dynamics, Oxidative Phosphorylation, Cell Line, Tumor, Drug Discovery, medicine, Cytotoxic T cell, Humans, Pharmacology, Messenger RNA, Chitosan, ATP synthase, biology, 010405 organic chemistry, Chemistry, Organic Chemistry, medicine.disease, 0104 chemical sciences, Cell biology, 010404 medicinal & biomolecular chemistry, Cancer cell, biology.protein, Molecular Medicine, Optic Atrophy 1, Mitochondrial fission, Drug Screening Assays, Antitumor, Energy Metabolism, Palladium
Abstract

In this work, we have successfully upgraded the crab wastes into Pd(II) complex of Gboxin analog-chitooligosaccharides conjugate (Pd(II)COS@GbA). This new complex has a high capacity to inhibit the proliferation of prostate cancer cells (IC50 = 1.92 μg/ml). This activity could be attributed to its ability to induce mitochondrial fragmentation through increasing mitochondrial fission dynamin-related protein 1 (p

Published
2019

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