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1. Amyloid peptide hydrogels via formation of coordination polymers with Ag+ by its core peptide equipped with a C-cysteine.

Author

Wang, Qian, Zhou, Fu-Peng, Tao, Dan-Dan, Wei, Jin-Hong, Cai, Rui, and Jiang, Yun-Bao

Subjects
PEPTIDES, C-terminal residues, AMYLOID, AMYLOID beta-protein
Abstract

We report that the core sequence of amyloid β (Aβ) peptide, KLVFF, when equipped with a C-terminal cysteine residue, exhibited an extremely low minimum hydrogelation concentration of 0.05 wt% in the presence of Ag+ in pH 5 buffer, with this concentration 2 orders of magnitude lower than that of the pentapeptide itself. The CD signal of the Ag+- L -KLVFFC hydrogel was observed to be sensitive to the early-stage aggregation of amyloid β peptide. [ABSTRACT FROM AUTHOR]

Published
2023
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