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Start Over Author "Huang, Junming" Language english Journal chemical communications

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1 results on '"Huang, Junming"'

1. A PEGylated megamer-based microRNA delivery system activatable by stepwise microenvironment stimulation.

Author

Wu, Wangteng, Hu, Qida, Wang, Meng, Shao, Shiyi, Zhao, Xinyu, Bai, Hongzhen, Huang, Junming, Tang, Guping, and Liang, Tingbo

Subjects
*MICRORNA, *LIVER cancer, *TUMOR microenvironment, *ACIDITY
Abstract

We developed a biodegradable, oncosensitive, megamer-based delivery system for miRNA therapy. The miRNA nanotherapeutics, activatable by stepwise stimulation of acidity and reduction mimicking tumor microenvironment, efficiently improve liver-specific miR-122 expression, increasing the possibility of translational application of miR-122 therapy against liver cancer. [ABSTRACT FROM AUTHOR]

Published
2019
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