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Herein, we describe a protocol for electrochemical cathode reduction to generate trifluoromethyl radicals. The trifluoromethylation reagent (IMDN-SO2CF3) used in this strategy is inexpensive and easy to obtain, and the reaction can be conducted efficiently without the addition of additional redox reagents. Using this strategy, we achieved electrochemical trifluoromethylation/cyclization for the synthesis of isoquinoline-1,3-diones and oxindoles. This protocol has good functional group tolerance and a broad substrate scope.

Herein, a new example of relay catalysis, using a combination of Mn2(CO)10 and an iridium-based photocatalyst, is reported. In our relay catalytic reaction, the Mn catalyst and iridium-based photocatalyst catalyze the reaction at different stages in the desired sequence under the same reaction conditions, and do not inhibit each other. This convenient method transforms a broad scope of alkyl iodides into the corresponding gem-difluoroalkenes via C(sp3)–C(sp3) bond construction. The protocol has good functional group tolerance and is suitable for the late-stage modification of multifunctional complex molecules.