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Your search keyword '"Zhong, Hua"' showing total 2 results
Start Over Author "Zhong, Hua" Topic apoptosis Journal chemical communications
2 results on '"Zhong, Hua"'

1. Distinct mechanisms for the pro-apoptotic conformational transition and alkaline transition in cytochrome cElectronic supplementary information (ESI) available: Experimental details and data. See DOI: 10.1039/b926261j.

Author

Ying, Tianlei, Wang, Zhong-Hua, Zhong, Fangfang, Tan, Xiangshi, and Huang, Zhong-Xian

Subjects
*CYTOCHROME c, *APOPTOSIS, *CONFORMATIONAL analysis, *HEMOPROTEINS, *BIOMOLECULES
Abstract

We demonstrate for the first time that cytochrome cundergoes a distinct pathway in the alkaline conformational transition from its pro-apoptotic conformational transition, which may have important functional consequences in vivo. [ABSTRACT FROM AUTHOR]

Published
2010
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2. Tyrosine-67 in cytochrome cis a possible apoptotic trigger controlled by hydrogen bonds viaa conformational transitionElectronic supplementary information (ESI) available: Experimental details and data. See DOI: 10.1039/b904347k.

Author

YingBoth authors contributed equally to this work., Tianlei, Wang, Zhong-Hua, Lin, Ying-Wu, Xie, Jin, Tan, Xiangshi, and Huang, Zhong-Xian

Subjects
*TYROSINE, *CYTOCHROME c, *APOPTOSIS, *HYDROGEN bonding, *CONFORMATIONAL analysis, *INTERMEDIATES (Chemistry)
Abstract

We found that cyt cY67H and Y67R variants represent a state which resembles the conformational intermediate state in cyt cwith high peroxidase activity; and also the hydrogen bond network around Tyr67 is associated with the conformational transition of cyt c; these suggest that the hydrogen bond network around Tyr67 is essential in maintaining the cyt cfunctioning not only as an electron transfer protein but also probably as a trigger in apoptosis. [ABSTRACT FROM AUTHOR]

Published
2009

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