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By employing DNAzyme as a recognition group and amplifier, and DNA-stabilized silver nanoclusters (DNA/AgNCs) as signal reporters, we reported for the first time a label-free catalytic and molecular beacon as an amplified biosensing platform for highly selective detection of cofactors such as Pb2+ and l-histidine. [ABSTRACT FROM AUTHOR]

Taking advantage of the super-quenching effect of the cationic perylene derivative on adjacent fluorophores, we for the first time reported a DNAzyme–perylene complex-based strategy for constructing fluorescence catalytic biosensors with improved sensitivity. [ABSTRACT FROM AUTHOR]

The use of a nanoscale DNA–Au dendrimer as a signal amplifier was proposed for the universal design of functional DNA-based ultra-sensitive SERS biosensors. This novel design combines the high specificity of functional DNA with the high sensitivity of surface-enhanced Raman scattering (SERS) spectroscopy, resulting in sensitivity superior to that of previously reported sensors. [ABSTRACT FROM AUTHOR]

A highly selective electrochemical biosensor for the ultrasensitive detection of Hg2+in aqueous solution has been developed based on the strong and specific binding of Hg2+by two DNA thymine bases (T–Hg2+–T) and the use of AuNP-functionalized reporter DNA to achieve signal amplification. [ABSTRACT FROM AUTHOR]