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Your search keyword '"Zhu, Chen"' showing total 3 results
Start Over Author "Zhu, Chen" Topic catalysis Journal chemical communications
3 results on '"Zhu, Chen"'

1. One-pot construction of functionalized aziridines and maleimides via a novel pseudo-Knoevenagel cascade reaction

Author

Jie Lei, Gui-Ting Song, Liu-Jun He, Ya-Fei Luo, Dian-Yong Tang, Hui-Kuan Lin, Brendan Frett, Hong-yu Li, Zhong-Zhu Chen, and Zhi-Gang Xu

Subjects
Molecular Structure, Cell Survival, 010405 organic chemistry, Aziridines, Metals and Alloys, Antineoplastic Agents, General Chemistry, 010402 general chemistry, 01 natural sciences, Catalysis, 0104 chemical sciences, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, Maleimides, Cell Line, Tumor, Materials Chemistry, Ceramics and Composites, Humans, Drug Screening Assays, Antitumor, Cell Proliferation
Abstract

An Ugi, novel pseudo-Knoevenagel, ring expansion cascade reaction was discovered and utilized for the synthesis of aziridinyl succinimides in one-pot. Subsequently, densely functionalized aziridines and maleimides have been designed and synthesized through similar cascade reactions. The target compounds were prepared by means of a mild reaction and a simple operation procedure, which could be applicable to a broad scope of starting materials. This series of novel cascade reactions generates opportunities for the tailored synthesis of a wide range of biologically active scaffolds through tuneable Ugi inputs. Discovery of compound 8i with comparable potency to sorafenib in liver cancer cell lines could provide a new avenue for liver cancer drug discovery.

Published
2020

2. A self-assembled nanoprobe for long-term cancer cell nucleus-specific staining and two-photon breast cancer imaging

Author

Shuanglian Wang, Wuwu Lv, Jie Dong, Wenbin Zeng, Hongliang Zeng, Zhu Chen, Ziping Wu, Tang Gao, Xueping Feng, and Mian Liu

Subjects
Light, Nucleolus, Contrast Media, Nanoprobe, Breast Neoplasms, 02 engineering and technology, 010402 general chemistry, 01 natural sciences, Fluorescence, Catalysis, Self assembled, Breast cancer, Two-photon excitation microscopy, Cell Line, Tumor, Materials Chemistry, medicine, Humans, Fluorescent Dyes, business.industry, Metals and Alloys, General Chemistry, 021001 nanoscience & nanotechnology, medicine.disease, 0104 chemical sciences, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, medicine.anatomical_structure, Cell Tracking, Cell culture, Cancer cell, Ceramics and Composites, Cancer research, Nanoparticles, Female, 0210 nano-technology, business, Nucleus, Cell Nucleolus
Abstract

Herein, a novel self-assembled nanoprobe for the long-term tracking of the nucleoli of cancer cells and for differentiating between clinical breast cancer tissues and para-carcinoma tissues has been developed.

Published
2018

3. Advances in allylic and benzylic C–H bond functionalization enabled by metallaphotoredox catalysis.

Author

Yue, Huifeng, Zhu, Chen, Huang, Long, Dewanji, Abhishek, and Rueping, Magnus

Subjects
*ORGANIC synthesis, *CATALYSIS, *CARBON-hydrogen bonds, *ALKYLBENZENES, *ALKENES, *CHEMICAL bonds
Abstract

Metallaphoto-catalysis has been established as a robust platform for efficient construction of a range of chemical bonds. Moreover, transformation of native functionalities such as C(sp3)–H bonds to produce functional molecules represents one of the most attractive strategies in organic synthesis. Merging two powerful methodologies, metallaphoto-catalyzed benzylic and allylic C(sp3)–H bond functionalizations provide a series of general and mild approaches for diversification of alkylbenzenes and alkenes. [ABSTRACT FROM AUTHOR]

Published
2022
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