1. Pore modulation of zirconium–organic frameworks for high-efficiency detection of trace proteins
- Author
-
Zhihong Zhang, Di-Ming Chen, Miao Du, Min Chen, Fenghe Duan, Chun-Sen Liu, Shuai Zhang, Minghua Wang, and Hui Zhao
- Subjects
Models, Molecular ,Materials science ,Aptamer ,High selectivity ,chemistry.chemical_element ,Nanotechnology ,Biosensing Techniques ,02 engineering and technology ,010402 general chemistry ,01 natural sciences ,Catalysis ,Protein detection ,Organometallic Compounds ,Materials Chemistry ,Particle Size ,TRACE (psycholinguistics) ,Detection limit ,Zirconium ,Metals and Alloys ,Electrochemical Techniques ,General Chemistry ,021001 nanoscience & nanotechnology ,0104 chemical sciences ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials ,chemistry ,Modulation ,Ceramics and Composites ,Muramidase ,0210 nano-technology ,Biosensor - Abstract
Tunable electrochemical biosensors based on analogous Zr-MOFs were developed for protein detection, the performances of which rely on the pore sizes and surroundings of the MOFs that show diverse binding behaviors to aptamers and then the targeted proteins. The optimized Zr-MOF-based sensor has high selectivity to lysozyme in a wide concentration range and a low detection limit of 3.6 pg mL−1, with good repeatability, stability, and applicability in real samples. This work will establish a new platform for biosensing and extend the application scope of MOF materials.
- Published
- 2017