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Start Over Author "Biao Jing" Journal chemical communications
2 results on '"Biao Jing"'

1. Derivatizing Nile Red fluorophores to quantify the heterogeneous polarity upon protein aggregation in the cell

Author

Rui Sun, Wang Wan, Wenhan Jin, Yulong Bai, Qiuxuan Xia, Mengdie Wang, Yanan Huang, Lianggang Zeng, Jialu Sun, Congcong Peng, Biao Jing, and Yu Liu

Subjects
Ionophores, Metals and Alloys, General Chemistry, equipment and supplies, complex mixtures, Catalysis, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, Protein Aggregates, Oxazines, Materials Chemistry, Ceramics and Composites, bacteria, sense organs, skin and connective tissue diseases, Fluorescent Dyes
Abstract

Protein aggregation in the cell is often manifested by the formation of subcellular punctate structures. Herein, we modulated the solvatochromism and solubility of Nile Red fluorophore derivatives to quantitatively study the polarity inside pathogenic protein aggregates, revealing structure- and protein-dependent polarity heterogeneity.

Published
2022
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2. Tailoring the positive and negative solvatochromism for chalcone analogues to detect heterozygous protein co-aggregation.

Author

Yulong, Bai, Wang, Wan, Yanan, Huang, Jichun, Wu, Lihua, Liu, Biao, Jing, Junlin, Chen, Xin, Zhang, and Yu, Liu

Subjects
SOLVATOCHROMISM, AMYOTROPHIC lateral sclerosis, SUPEROXIDE dismutase, CHALCONES, PROTEINS
Abstract

It is rare for one fluorophore scaffold to harbor both positive and negative solvatochromism. Herein, we tailor chalcone analogues to achieve both positive- and negative-polarity sensitivity of fluorescence intensity. We explore two chalcones of opposite solvatochromism to simultaneously detect the co-aggregation of wild-type and mutant superoxide dismutase that cause amyotrophic lateral sclerosis disease. [ABSTRACT FROM AUTHOR]

Published
2023
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