Search

Your search keyword '"Chen, Jianmei"' showing total 2 results
Start Over Author "Chen, Jianmei" Journal chemical communications
2 results on '"Chen, Jianmei"'

1. Rational design of multifunctional small-molecule prodrugs for simultaneous suppression of cancer cell growth and metastasis in vitro and in vivo.

Author

Xie, Haiyang, Xu, Xiao, Chen, Jianmei, Li, Lingling, Wang, Jianguo, Fang, Tao, Zhou, Lin, Wang, Hangxiang, and Zheng, Shusen

Subjects
*METASTASIS, *CANCER cell growth, *CANCER treatment, *APOPTOSIS, *CANCER cells, *PREVENTION
Abstract

We present a design concept for multifunctional prodrugs that simultaneously induce apoptosis and suppress cancer cell metastasis in vitro and in vivo. These “all-in-one” prodrug constructs possess therapeutic potential as novel “integrative” platforms for metastatic cancer treatment. [ABSTRACT FROM AUTHOR]

Published
2016
Full Text
View/download PDF

2. A potent free fatty acid receptor 1 agonist with a glucose-dependent antihyperglycemic effect.

Author

Wang, Xuekun, Xu, Yurui, Feng, Shujun, Huang, Xinyu, Meng, Xia, Chen, Jiao, Guo, Leilei, Ge, Junliang, Zhang, Jikang, Chen, Jianmei, Cheng, Li, Gu, Kai, Zhang, Yu, Jiang, Qing, and Ning, Xinghai

Subjects
*FREE fatty acids, *SECRETION, *INSULIN
Abstract

We present a novel free fatty acid receptor 1 (FFA1) agonist, named PAFA, with a strong agonist potency (EC50 = 6.04 nM) and good serum stability. PAFA significantly stimulates insulin secretion in INS-1 cells in a glucose-dependent manner and exhibits high antihyperglycemic effects in db/db mice without adverse effects. [ABSTRACT FROM AUTHOR]

Published
2019
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results