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Your search keyword '"Cloonan, Suzanne M."' showing total 1 results
Start Over Author "Cloonan, Suzanne M." Journal chemical communications
1 results on '"Cloonan, Suzanne M."'

1. Quaternarized pdppz: synthesis, DNA-binding and biological studies of a novel dppz derivative that causes cellular death upon light irradiationElectronic supplementary information (ESI) available: Synthesis, 22 figures and 2 tables. See DOI: 10.1039/c0cc04303f

Author

Elmes, Robert B. P., Erby, Marialuisa, Cloonan, Suzanne M., Quinn, Susan J., Williams, D. Clive, and Gunnlaugsson, Thorfinnur

Subjects
ORGANIC synthesis, DNA-ligand interactions, APOPTOSIS, CANCER cells, CELL lines, IRRADIATION
Abstract

The quaternarized pdppz derivative 1was shown to bind strongly to DNA with concomitant changes in its ground and excited state photophysical properties. Furthermore, the compound also showed rapid cellular uptake, and induced apoptosis upon light irradiation in various cancer cell lines after 24 hours of incubation. [ABSTRACT FROM AUTHOR]

Published
2010

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