1. A peptide-based four-color fluorescent polydopamine nanoprobe for multiplexed sensing and imaging of proteases in living cells
- Author
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Lifang Yao, Yong Huang, Lina Fang, Ming Shi, Hong Liang, Jiayao Xu, Shulin Zhao, and Liangliang Zhang
- Subjects
Proteases ,Indoles ,Polymers ,medicine.medical_treatment ,Nanoprobe ,Peptide ,010402 general chemistry ,01 natural sciences ,Catalysis ,Cathepsin B ,Cell Line, Tumor ,Materials Chemistry ,medicine ,Humans ,Fluorescent Dyes ,chemistry.chemical_classification ,Protease ,010405 organic chemistry ,Chemistry ,Metals and Alloys ,General Chemistry ,Carbocyanines ,Urokinase-Type Plasminogen Activator ,Fluorescence ,0104 chemical sciences ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials ,Cell biology ,Microscopy, Fluorescence ,Cell culture ,Molecular Probes ,Ceramics and Composites ,Matrix Metalloproteinase 2 ,Nanoparticles ,Peptides ,Peptide Hydrolases - Abstract
We develop a novel peptide-based four-color fluorescent polydopamine nanoprobe for multiplexed sensing and imaging of tumor-related proteases in living cells. This nanoprobe responds rapidly and selectively, enabling simultaneous and high-contrast imaging of multiple proteases in living cells. Furthermore, it could detect the changes of protease expression in living cells.
- Published
- 2019
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