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Start Over Author "Liu, Jianbo" Journal chemical communications
20 results on '"Liu, Jianbo"'

1. Covalent PROTAC design method based on a sulfonyl pyridone probe.

Author

Luo, Qinhong, Wang, Yaqi, Hou, Zhanfeng, Liang, Huiting, Tu, Licheng, Xing, Yun, Wan, Chuan, Liu, Jianbo, Wang, Rui, Zhu, Lizhi, Han, Wei, Wu, Jianlong, Lu, Fei, Yin, Feng, and Li, Zigang

Subjects
PYRIDONE, AMINO acids, PROTEIN engineering, PROTEOLYSIS, CYSTEINE, WARHEADS
Abstract

Covalent proteolysis-targeting chimeras (PROTACs) offer enhanced selectivity, prolonged action, and increased efficacy against challenging target proteins. The conventional approach relies on covalent ligands, but our study presents an innovative method employing an N-sulfonyl pyridone warhead to selectively target tyrosine (Tyr) residues. The von Hippel–Lindau (VHL) moiety is transferred from the warhead to the exposed Tyr, allowing us to design a STING degrader (DC50 0.53 μM, Dmax 56.65%). This approach showcases the potential of nucleophilic amino acid labeling probes, particularly for proteins lacking easily accessible cysteine residues, opening new possibilities for covalent PROTAC design and targeted protein degradation therapies. [ABSTRACT FROM AUTHOR]

Published
2024
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2. Covalent PROTAC design method based on sulfonyl pyridone probe

Author

Luo, Qinhong, primary, Wang, Yaqi, additional, Hou, Zhanfeng, additional, Liang, Huiting, additional, Tu, Licheng, additional, Xing, Yun, additional, Wan, Chuan, additional, Liu, Jianbo, additional, WANG, Rui, additional, Zhu, Lizhi, additional, Han, Wei, additional, Wu, Jianlong, additional, Lu, Fei, additional, Yin, Feng, additional, and Li, Zigang, additional

Published
2023
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14. Temperature-responsive split aptamers coupled with polymerase chain reaction for label-free and sensitive detection of cancer cells.

Author

Tang, Jinlu, He, Xiaoxiao, Lei, Yanli, Shi, Hui, Guo, Qiuping, Liu, Jianbo, He, Dinggeng, Yan, Lv’an, and Wang, Kemin

Subjects
POLYMERASE chain reaction, TEMPERATURE effect, COUPLING reactions (Chemistry)
Abstract

A label-free and general thermo-controlled split apta-PCR strategy was first developed for the sensitive and specific detection of cancer cells. By integrating the temperature-responsive function of split aptamers with PCR amplification, a facile fluorescence assay of liver cancer SMMC-7721 cells was successfully realized with the detection of as low as 100 cells. [ABSTRACT FROM AUTHOR]

Published
2017
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17. Peptide-tailored assembling of Aunanorods

Author

He, Weiwei, primary, Hou, Shuai, additional, Mao, Xiaobo, additional, Wu, Xiaochun, additional, Ji, Yinglu, additional, Liu, Jianbo, additional, Hu, Xiaona, additional, Zhang, Ke, additional, Wang, Chenxuan, additional, Yang, Yanlian, additional, and Wang, Qi, additional

Published
2011
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20. Peptide-tailored assembling of Au nanorods.

Author

Hou, Shuai, Mao, Xiaobo, Wu, Xiaochun, Ji, Yinglu, Liu, Jianbo, Hu, Xiaona, Zhang, Ke, Wang, Chenxuan, Yang, Yanlian, and Wang, Qi

Subjects
PEPTIDES, MOLECULAR self-assembly, COLLOIDAL gold, PYRIDINE, THIOLS, CHEMICAL detectors
Abstract

By investigating the influence of peptides on the assembling process of Au nanorods induced by 4-mercaptopyridine, two kinds of peptides were identified. The nature of peptides plays an important role in tailoring assembling, which makes potential peptide recognition and detection possible. [ABSTRACT FROM AUTHOR]

Published
2011

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