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Start Over Descriptor "QUANTUM dot device design & construction" Journal chemical communications
1 results on '"QUANTUM dot device design & construction"'

1. Single quantum dot-based nanosensor for rapid and sensitive detection of terminal deoxynucleotidyl transferase.

Author

Wang, Li-Juan, Luo, Ming-Li, Zhang, Qianyi, Tang, Bo, and Zhang, Chun-Yang

Subjects
*NANOSENSORS, *TRANSFERASES, *QUANTUM dot device design & construction, *EXONUCLEASES, *FLUORESCENCE resonance energy transfer
Abstract

We developed a simple and rapid method for terminal deoxynucleotidyl transferase (TdT) assay on the basis of the polymerization-directed exonuclease-assisted construction of a single quantum dot (QD)-based fluorescence resonance energy transfer (FRET) nanosensor. This method is very sensitive with a detection limit as low as 1 × 10−6 U μL−1, and it can be used for the screening of TDT inhibitors and accurate quantification of TdT activity even in 5 cancer cells. [ABSTRACT FROM AUTHOR]

Published
2017
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