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Start Over Author "Rossberg, André" Journal chemical communications
4 results on '"Rossberg, André"'

3. Destabilization of DNA through interstrand crosslinking by UO22+.

Author

Rossberg, André, Abe, Takaya, Okuwaki, Koji, Barkleit, Astrid, Fukuzawa, Kaori, Nakano, Tatsuya, Mochizuki, Yuji, and Tsushima, Satoru

Subjects
*CROSSLINKING of nucleic acids, *HYDROGEN bonding, *BASE pairs
Abstract

UO22+ was shown to form an interstrand crosslink between two different strands of a single DNA molecule. This crosslink hardly affected the hydrogen bonds between nucleobase pairs but destabilized the π–π stacking between the two nucleobases in the vicinity of UO22+-bound phosphate. Thereby, the fragility of the DNA backbone increased upon UO22+ binding. [ABSTRACT FROM AUTHOR]

Published
2019
Full Text
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4. Destabilization of DNA through interstrand crosslinking by UO22+.

Author

Rossberg, André, Abe, Takaya, Okuwaki, Koji, Barkleit, Astrid, Fukuzawa, Kaori, Nakano, Tatsuya, Mochizuki, Yuji, and Tsushima, Satoru

Subjects
CROSSLINKING of nucleic acids, HYDROGEN bonding, BASE pairs
Abstract

UO22+ was shown to form an interstrand crosslink between two different strands of a single DNA molecule. This crosslink hardly affected the hydrogen bonds between nucleobase pairs but destabilized the π–π stacking between the two nucleobases in the vicinity of UO22+-bound phosphate. Thereby, the fragility of the DNA backbone increased upon UO22+ binding. [ABSTRACT FROM AUTHOR]

Published
2019
Full Text
View/download PDF

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