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Start Over Author "Tay, Daniel Weiliang" Journal chemical communications
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1. Enantioselective synthesis of 2-substituted and 3-substituted piperidines through a bromoaminocyclization process.

Author

Zhou, Ling, Tay, Daniel Weiliang, Chen, Jie, Leung, Gulice Yiu Chung, and Yeung, Ying-Yeung

Subjects
*AMIDES, *THIOCARBAMATES, *CATALYSTS, *SODIUM salts, *DOPAMINERGIC mechanisms
Abstract

A catalytic enantioselective bromocyclization of olefinic amides using amino-thiocarbamates as the catalysts has been developed. The resulting enantioenriched 2-substituted 3-bromopiperidines can readily be transformed to 3-substituted piperidines through a silver salt-mediated rearrangement. This process has been applied to the synthesis of a dopaminergic drug, Preclamol. [ABSTRACT FROM AUTHOR]

Published
2013
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