1. Chemoenzymatic synthesis of α-dystroglycan core M1 O-mannose glycans
- Author
-
Zhang, Yan, Meng, Caicai, Jin, Lan, Chen, Xi, Wang, Fengshan, and Cao, Hongzhi
- Subjects
Medicinal and Biomolecular Chemistry ,Organic Chemistry ,Chemical Sciences ,Clinical Research ,Aldehyde-Lyases ,Bacterial Proteins ,Dystroglycans ,Glycosylation ,Mannose ,Polysaccharides ,Transferases ,UDPglucose 4-Epimerase ,Chemical sciences ,Engineering - Abstract
The diversity-oriented chemoenzymatic synthesis of α-dystroglycan (α-DG) core M1 O-mannose glycans has been achieved via a three-step sequential one-pot multienzyme (OPME) glycosylation of a chemically prepared disaccharyl serine intermediate. The high flexibility and efficiency of this chemoenzymatic strategy was demonstrated for the synthesis of three more complex core M1 O-mannose glycans for the first time along with three previously reported core M1 structures.
- Published
- 2015