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Start Over Author "Yakushiji, Fumika" Journal chemical communications
1 results on '"Yakushiji, Fumika"'

1. Beneficial effects of a new neuroprotective compound in neuronal cells and MPTP-administered mouse model of Parkinson's disease.

Author

Kato, Izumi, Ogawa, Yudai, Yakushiji, Fumika, Ogura, Jiro, Kobayashi, Masaki, Shindo, Naoya, Ichikawa, Satoshi, Maenaka, Katsumi, and Sakaitani, Masahiro

Subjects
PARKINSON'S disease, LABORATORY mice, ANIMAL disease models, NEUROPROTECTIVE agents, OXIDATIVE stress
Abstract

A new compound, a derivative of 3,4,5-trimethoxy-N-phenyl benzamide bearing an 8′′-methylimidazopyridine moiety, is found to demonstrate neuroprotective effects by preventing cell death caused by oxidative stress. The compound possesses high solubility and metabolic stability, and inhibits MPTP-induced effects in vivo, indicating high potential as a therapeutic drug for Parkinson's disease. [ABSTRACT FROM AUTHOR]

Published
2023
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