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A metal-free method for the dual activation of aryl phosphinate has been developed; the P–H and P–O bonds are sequentially activated by the Tf2O/DMSO system. Without the requirement of metals and unstable P-reagents, this one-pot procedure provides a convenient and practical access to a variety of aryl phosphonates. A mechanism involving twice generation of electrophilic P-species and two SN-processes is proposed on the basis of the control experiments. [ABSTRACT FROM AUTHOR]

The first Cu-catalyzed cascade sp3 C–H bond oxidative functionalization of the 2-ethylazaarenes has been developed. The two different sp3 C–H bonds in 2-ethylazaarenes are selectively oxidized and four new types of bonds (C=O, C=N, C–C, C–O) are constructed in one operation. Starting from the simple substrates and cheap nitro source, this reaction provides an efficient approach to produce new kinds of isoxazolines. [ABSTRACT FROM AUTHOR]

A novel metal-free oxidative carbonitration of alkenes by a nitration and C–H functionalization cascade process has been developed. This methodology provides an efficient way to construct valuable nitro-containing oxindoles. [ABSTRACT FROM AUTHOR]

A novel protocol for the preparation of various 3-alkylideneoxindoles viaa silver-catalyzed aromatic C–H functionalization has been developed. The process is simple, environmentally conscious, and avoids the use of abundant bases, oxidants, or other additives. [ABSTRACT FROM AUTHOR]

An oxidative homo dimerization of N-protected and free indole derivatives toward bioactive 3,3′-linked biindolyl scaffolds viaPd-catalyzed direct C–H transformations was first successfully demonstrated. [ABSTRACT FROM AUTHOR]

A novel metal-free oxidative carbonitration of alkenes by a nitration and C–H functionalization cascade process has been developed. This methodology provides an efficient way to construct valuable nitro-containing oxindoles. [ABSTRACT FROM AUTHOR]