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Start Over Author "Ye, Zhijian" Journal chemical communications
4 results on '"Ye, Zhijian"'

3. Niacin-ligated platinum(IV)–ruthenium(II) chimeric complexes synergistically suppress tumor metastasis and growth with potentially reduced toxicity in vivo.

Author

Shu, Liwei, Ren, Lulu, Wang, Yuchen, Fang, Tao, Ye, Zhijian, Han, Weidong, Chen, Chao, and Wang, Hangxiang

Subjects
PLATINUM, METASTASIS, TUMOR growth, CELL proliferation, CISPLATIN
Abstract

Niacin-ligated platinum(IV)–ruthenium(II) chimeric complexes (PtRu 1–4) have been synthesized and evaluated for their antitumor performance. Using the optimal complex, PtRu-1, we show that this water-soluble chimeric prodrug not only potently inhibits the metastasis and proliferation of tumor cells but also has an unexpectedly higher safety margin in animals compared with the traditionally-used, clinically approved drug cisplatin. [ABSTRACT FROM AUTHOR]

Published
2020
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