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Start Over Author "You Zi" Journal chemical communications
6 results on '"You Zi"'

3. Lewis-base-catalysed selective reductions of ynones with a mild hydride donor

Author

You Zi, Fritz Schömberg, and Ivan Vilotijevic

Subjects
010405 organic chemistry, Chemistry, Hydride, Metals and Alloys, General Chemistry, 010402 general chemistry, 01 natural sciences, Combinatorial chemistry, Catalysis, 0104 chemical sciences, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, Nucleophile, Propargyl, Materials Chemistry, Ceramics and Composites, Lewis acids and bases
Abstract

Ynones are efficiently reduced with a mild hydride donor in the presence of a catalytic amount of nucleophilic phosphines. The reactions are selective 1,2-reductions that give propargyl alcohols in yields of up to 96%. It is proposed that success in these reactions depends on the activation of ynones by a Lewis base catalyst. A protic additive plays a key role in suppressing the undesired reaction pathways and accelerating the 1,2-reductions.

Published
2018
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4. Metal-free oxidative direct C(sp3)–H bond functionalization of ethers with α,α-diaryl allylic alcohols

Author

Xiao-Ping Xu, You Zi, Hua Meng, Shun-Jun Ji, and Xue-Qiang Chu

Subjects
Allylic rearrangement, Hydrogen bond, Chemistry, Metals and Alloys, General Chemistry, Oxidative phosphorylation, Medicinal chemistry, Catalysis, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, Metal free, Materials Chemistry, Ceramics and Composites, Organic chemistry, Surface modification
Abstract

A metal-free method for direct C(sp3)–H bond functionalization of simple ethers with α,α-diaryl allylic alcohols is described. The established protocol provides facile access to α-aryl-β-oxyalkylated carbonyl ketones via radical addition and a 1,2-aryl migration cascade process. An application of the product has been demonstrated in the synthesis of a serotonin antagonist.

Published
2014
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5. Metal-free oxidative direct C(sp³)--H bond functionalization of ethers with α,α-diaryl allylic alcohols.

Author

Xue-Qiang Chu, Hua Meng, You Zi, Xiao-Ping Xu, and Shun-Jun Ji

Subjects
HYDROGEN bonding, ETHERS, ALLYL alcohol, CARBONYL compounds, KETONES
Abstract

A metal-free method for direct C(sp³)-H bond functionalization of simple ethers with α,α-diaryl allylic alcohols is described. The established protocol provides facile access to α-aryl-β-oxyalkylated carbonyl ketones via radical addition and a 1,2-aryl migration cascade process. An application of the product has been demonstrated in the synthesis of a serotonin antagonist. [ABSTRACT FROM AUTHOR]

Published
2014
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6. Radical phosphinylation of α,α-diaryl allylic alcohols with concomitant 1,2-aryl migration.

Author

Xue-Qiang Chu, You Zi, Hua Meng, Xiao-Ping Xu, and Shun-Jun Ji

Subjects
*ALLYL alcohol, *ORGANOPHOSPHORUS compounds, *TRANSITION metal catalysts, *ARYL group, *CARBONYL compounds, *OXIDIZING agents
Abstract

A novel radical phosphinylation of α,α-diaryl allylic alcohols with arylphosphine oxides was described for the direct preparation of α-aryl-β-phosphinylated carbonyl ketones in medium to good yields via 1,2-aryl migration. In this reaction, formation of new C(Ar)-C(sp³) and C(sp³)-P bonds was observed. [ABSTRACT FROM AUTHOR]

Published
2014
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