1. Teaching indicators to unravel the kinetic features of host-guest inclusion complexes
- Author
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Laura Grimm, Zsombor Miskolczy, Amrutha Prabodh, Stephan Sinn, László Biczók, Frank Biedermann, Stefan Bräse, and Mónika Megyesi
- Subjects
Bridged-Ring Compounds ,Chemistry & allied sciences ,Supramolecular chemistry ,macromolecular substances ,Kinetic energy ,Catalysis ,Dissociation (chemistry) ,Computational chemistry ,Materials Chemistry ,medicine ,Humans ,Kinetic rate constant ,Serum Albumin ,Fluorescent Dyes ,Chemistry ,Metals and Alloys ,Imidazoles ,General Chemistry ,Human serum albumin ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials ,Kinetics ,ddc:540 ,Ceramics and Composites ,Thermodynamics ,medicine.drug - Abstract
Both thermodynamic and kinetic insights are needed for a proper analysis of association and dissociation processes of host–guest interactions. However, kinetic descriptions of supramolecular systems are scarce in the literature because suitable experimental protocols are lacking. We introduce here three time-resolved methods that allow for convenient determination of kinetic rate constants of spectroscopically silent or even insoluble guests with the macrocyclic cucurbit[n]uril family and human serum albumin (HSA) protein as representative hosts.
- Published
- 2020