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Start Over Author "Lifang Yao" Journal chemical communications (cambridge, england)
1 results on '"Lifang Yao"'

1. A gold nanoparticle-based four-color proximity immunoassay for one-step, multiplexed detection of protein biomarkers using ribonuclease H signal amplification

Author

Lina Fang, Yong Huang, Shulin Zhao, Jiayao Xu, Hong Liang, Wenting Chen, Zhen-Feng Chen, Ming Shi, and Lifang Yao

Subjects
Ribonuclease H, Nanoparticle, Color, Metal Nanoparticles, One-Step, 02 engineering and technology, Biosensing Techniques, 010402 general chemistry, Mass spectrometry, 01 natural sciences, Catalysis, Fluorescence, Materials Chemistry, medicine, RNase H, Detection limit, Immunoassay, Chromatography, medicine.diagnostic_test, biology, Chemistry, Dynamic range, Metals and Alloys, Proteins, General Chemistry, 021001 nanoscience & nanotechnology, 0104 chemical sciences, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, Spectrometry, Fluorescence, Ceramics and Composites, biology.protein, Gold, 0210 nano-technology, Biomarkers
Abstract

A novel gold nanoparticle-based four-color fluorescence proximity immunoassay is developed for one-step, multiplexed detection of protein biomarkers using ribonuclease H signal amplification. This assay could detect proteins with detection limits down to pg mL−1 and a 5-log dynamic range. Furthermore, it is suitable for rapid, direct quantification of multiple proteins in biological samples.

Published
2018

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