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Start Over Author "Sheng-Yang Ho" Journal chemical communications (cambridge, england)
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1. Utilizing an iron(iii)-chelation masking strategy to prepare mono- and bis-functionalized aerobactin analogues for targeting pathogenic bacteria

Author

Cheng-Chih Hsu, Sheng-Yang Ho, Jiun-Jie Shie, Yu-Hin Ho, and Tsung-Shing Andrew Wang

Subjects
Masking (art), Stereochemistry, Microbial Sensitivity Tests, 010402 general chemistry, medicine.disease_cause, Hydroxamic Acids, Iron Chelating Agents, 01 natural sciences, Catalysis, chemistry.chemical_compound, Materials Chemistry, medicine, Chelation, Carboxylate, 010405 organic chemistry, Metals and Alloys, Pathogenic bacteria, General Chemistry, 0104 chemical sciences, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, Klebsiella pneumoniae, chemistry, Ceramics and Composites, bacteria, Surface modification, Aerobactin, Selectivity
Abstract

A direct and selective method for the functionalization of aerobactin has been described. Selectivity was achieved by masking the functioning carboxylate via iron-chelation, leaving the two remaining carboxylates for direct modification. Both mono- and bis-functionalized aerobactin effectively targeted pathogenic bacteria, showing a facile method with prospective applications.

Published
2017

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