1. Development of a new colorimetric and red-emitting fluorescent dual probe for G-quadruplex nucleic acids
- Author
-
Jin-wu Yan, Jia-Heng Tan, Tian-Miao Ou, Lian-Quan Gu, Wen-Jie Ye, Shuo-Bin Chen, Ding Li, Hui-Yun Liu, and Zhi-Shu Huang
- Subjects
Fluorophore ,Lung Neoplasms ,G-quadruplex ,DNA, Ribosomal ,Catalysis ,chemistry.chemical_compound ,Alkaloids ,Materials Chemistry ,Humans ,heterocyclic compounds ,Fluorescent Dyes ,Isaindigotone ,Molecular Structure ,Chemistry ,Metals and Alloys ,RNA-Binding Proteins ,General Chemistry ,DNA ,Phosphoproteins ,Fluorescence ,Combinatorial chemistry ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials ,G-Quadruplexes ,Visual detection ,Spectrometry, Fluorescence ,Ceramics and Composites ,Nucleic acid ,Dual probe ,Quinazolines ,Colorimetry ,Indicators and Reagents ,HeLa Cells - Abstract
A tailor-made colorimetric and red-emitting fluorescent dual probe for G-quadruplex nucleic acids was developed by incorporating a coumarin–hemicyanine fluorophore into an isaindigotone framework. The significant and distinct changes in both the color and fluorescence of this probe enable the label-free and visual detection of G-quadruplex structures.
- Published
- 2014