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Your search keyword '"Lv MM"' showing total 4 results
Start Over Author "Lv MM" Journal chemical communications cambridge england
4 results on '"Lv MM"'

1. Proximity ligation-transcription circuit-powered exponential amplifications for single-molecule monitoring of telomerase in human cells.

Author

Wang LJ, Lv MM, Hu JP, Liu M, and Zhang CY

Subjects
Humans, HeLa Cells, Telomerase metabolism
Abstract

We develop a new strategy for single-molecule monitoring of telomerase based on proximity ligation-transcription circuit-powered exponential amplifications. This strategy exhibits high sensitivity with a detection limit of 0.1 aM for the synthetic telomerase product TPC4 in vitro and 1 HeLa cell in vivo . Moreover, it can screen potential inhibitors, discriminate telomerase from interferents, and distinguish cancer cells from normal cells.

Published
2023
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2. Three-dimensional DNA nanostructures for dual-color microRNA imaging in living cells via hybridization chain reaction.

Author

Lv MM, Wu Z, Yu RQ, and Jiang JH

Subjects
Cell Survival, MicroRNAs genetics, Nucleic Acid Hybridization, Color, DNA chemistry, MicroRNAs analysis, Nanostructures chemistry, Optical Imaging
Abstract

A well-defined 3D DNA nanostructure with precise composition was developed by stoichimetric combination of a DNA tetrahedron and Y-shaped DNA, which allowed multiplexed, signal-amplified fluorescence imaging of miRNAs in living cells via hybridization chain reaction.

Published
2020
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3. DNAzyme activated protein-scaffolded CRISPR-Cas9 nanoassembly for genome editing.

Author

Zhu X, Lv MM, Liu JW, Yu RQ, and Jiang JH

Subjects
Biotin chemistry, Cell Line, Tumor, Gene Editing methods, Green Fluorescent Proteins genetics, Green Fluorescent Proteins metabolism, Humans, Nucleic Acid Hybridization, RNA, Guide, CRISPR-Cas Systems genetics, Streptavidin chemistry, CRISPR-Associated Protein 9 genetics, CRISPR-Cas Systems genetics, DNA, Catalytic genetics, Nanostructures chemistry
Abstract

A novel self-assembled protein-scaffolded CRISPR-Cas9 nanosystem for facile and efficient gene editing in a DNAzyme-controlled manner has been developed.

Published
2019
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4. Target induced reconstruction of DNAzymatic amplifier nanomachines in living cells for concurrent imaging and gene silencing.

Author

Li JJ, Li WN, Du WF, Lv MM, Wu ZK, and Jiang JH

Subjects
Carbocyanines chemistry, Cell Line, Tumor, DNA, Catalytic genetics, DNA, Single-Stranded genetics, Early Growth Response Protein 1 genetics, Early Growth Response Protein 1 metabolism, Fluorescent Dyes chemistry, Humans, Microscopy, Confocal, Nucleic Acid Amplification Techniques instrumentation, Nucleic Acid Hybridization, RNA, Messenger genetics, Biosensing Techniques methods, DNA, Catalytic chemistry, DNA, Single-Stranded chemistry, Gene Silencing, Nanostructures chemistry, RNA, Messenger metabolism, Theranostic Nanomedicine methods
Abstract

A novel DNAzymatic amplifier nanomachine that is reconstructed in response to an mRNA input has been developed to enable the functions of concurrent sensitive mRNA imaging and activatable gene therapy in living cells.

Published
2018
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