28 results on '"Spring, David R."'
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2. Site-selective peptide functionalisation mediated via vinyl-triazine linchpins.
3. Disulfide re-bridging reagents for single-payload antibody-drug conjugates.
4. Peroxide-cleavable linkers for antibody-drug conjugates.
5. Antibody dual-functionalisation enabled through a modular divinylpyrimidine disulfide rebridging strategy.
6. Development of small cyclic peptides targeting the CK2α/β interface.
7. Divinylpyrimidine reagents generate antibody-drug conjugates with excellent in vivo efficacy and tolerability.
8. A dual-enzyme cleavable linker for antibody-drug conjugates.
9. C(sp 3 )-H arylation to construct all-syn cyclobutane-based heterobicyclic systems: a novel fragment collection.
10. An efficient, stereocontrolled and versatile synthetic route to bicyclic partially saturated privileged scaffolds.
11. Fsp 3 -rich and diverse fragments inspired by natural products as a collection to enhance fragment-based drug discovery.
12. Total synthesis and biological evaluation of simplified aplyronine analogues as synthetically tractable anticancer agents.
13. Macrocyclisation and functionalisation of unprotected peptides via divinyltriazine cysteine stapling.
14. Targeted covalent inhibitors of MDM2 using electrophile-bearing stapled peptides.
15. Computationally-guided optimization of small-molecule inhibitors of the Aurora A kinase-TPX2 protein-protein interaction.
16. Coumarin-derived transformable fluorescent sensor for Zn2+.
17. A selective and ratiometric Cu2+ fluorescent probe based on naphthalimide excimer-monomer switching.
18. Development of off-on fluorescent probes for heavy and transition metal ions.
19. Diversity-oriented synthesis of bicyclic and tricyclic alkaloids.
20. 3D small-molecule microarrays.
21. The discovery of antibacterial agents using diversity-oriented synthesis.
22. Towards quorum-quenching catalytic antibodies.
23. Identification of an anti-MRSA dihydrofolate reductase inhibitor from a diversity-oriented synthesis.
24. Exploiting domino enyne metathesis mechanisms for skeletal diversity generation.
25. Fluorous tagged small molecule microarrays.
26. Copper catalyzed oxidation of organozinc halides.
27. Skeletal diversity construction via a branching synthetic strategy.
28. Aryl-aryl coupling via directed lithiation and oxidation.
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