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Your search keyword '"Staderini, M."' showing total 2 results
Start Over Author "Staderini, M." Journal chemical communications cambridge england
2 results on '"Staderini, M."'

1. Polymyxin-based photosensitizer for the potent and selective killing of Gram-negative bacteria.

Author

Ucuncu M, Mills B, Duncan S, Staderini M, Dhaliwal K, and Bradley M

Subjects
Animals, Anti-Bacterial Agents chemistry, Erythrocytes drug effects, Escherichia coli growth & development, Escherichia coli Infections drug therapy, Hemolysis drug effects, Humans, Light, Methylene Blue chemistry, Photochemotherapy, Photosensitizing Agents chemistry, Polymyxin B chemistry, Pseudomonas aeruginosa growth & development, Skin drug effects, Skin microbiology, Skin radiation effects, Swine, Anti-Bacterial Agents administration & dosage, Escherichia coli drug effects, Methylene Blue administration & dosage, Photosensitizing Agents administration & dosage, Polymyxin B administration & dosage, Pseudomonas aeruginosa drug effects
Abstract

Here we report the synthesis of a novel methylene blue-polymyxin conjugate and demonstrate its light-mediated killing of Gram-negative bacteria on skin models of infection demonstrating a 10 8 decrease in bacterial colony-forming units.

Published
2020
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2. Electrodrugs: an electrochemical prodrug activation strategy.

Author

Norman DJ, González-Fernández E, Clavadetscher J, Tucker L, Staderini M, Mount AR, Murray AF, and Bradley M

Subjects
Antineoplastic Agents chemistry, Apoptosis drug effects, Coordination Complexes chemical synthesis, Coordination Complexes chemistry, Electrodes, HCT116 Cells, Humans, Organoplatinum Compounds chemical synthesis, Organoplatinum Compounds chemistry, Oxidation-Reduction, Prodrugs chemical synthesis, Prodrugs chemistry, Antineoplastic Agents pharmacology, Coordination Complexes pharmacology, Electrochemical Techniques methods, Organoplatinum Compounds pharmacology, Prodrugs pharmacology
Abstract

The term electroceutical has been used to describe implanted devices that deliver electrical stimuli to modify biological function. Herein, we describe a new concept in electroceuticals, demonstrating for the first time the electrochemical activation of metal-based prodrugs. This is illustrated by the controlled activation of Pt(iv) prodrugs into their active Pt(ii) forms within a cellular context allowing selectivity and control of where, when and how much active drug is generated.

Published
2018
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