Search

Your search keyword '"Vangala Venugopal"' showing total 2 results
Start Over Author "Vangala Venugopal" Journal chemical communications cambridge england
2 results on '"Vangala Venugopal"'

1. A lysosome-specific near-infrared fluorescent probe for in vitro cancer cell detection and non-invasive in vivo imaging.

Author

Mengji R, Acharya C, Vangala V, and Jana A

Subjects
Animals, Female, HEK293 Cells, Humans, Infrared Rays, Lysosomes chemistry, Mice, Mice, Inbred C57BL, Microscopy, Fluorescence, Neoplasms, Experimental diagnostic imaging, Fluorescent Dyes chemistry, Optical Imaging
Abstract

Near-infrared (NIR) fluorescent probes have been developed as potential bio-materials having profound applications in diagnosis and clinical practice. Herein, we wish to disclose a highly photostable ultra-bright NIR probe for the specific detection of lysosomes in numerous cell lines. Furthermore, the applicability of the developed NIR probe was evaluated for in vivo imaging.

Published
2019
Full Text
View/download PDF

2. Redox-responsive xanthene-coumarin-chlorambucil-based FRET-guided theranostics for "activatable" combination therapy with real-time monitoring.

Author

Gangopadhyay M, Mengji R, Paul A, Venkatesh Y, Vangala V, Jana A, and Singh NDP

Subjects
Antineoplastic Agents chemical synthesis, Antineoplastic Agents pharmacology, Antineoplastic Agents radiation effects, Chlorambucil chemical synthesis, Chlorambucil radiation effects, Combined Modality Therapy methods, Drug Therapy methods, Fluorescence, Glutathione chemistry, HEK293 Cells, HeLa Cells, Humans, Light, Photochemotherapy methods, Photosensitizing Agents chemical synthesis, Photosensitizing Agents pharmacology, Photosensitizing Agents radiation effects, Prodrugs chemical synthesis, Prodrugs radiation effects, Singlet Oxygen chemistry, Theranostic Nanomedicine, Umbelliferones chemical synthesis, Umbelliferones radiation effects, Xanthenes chemical synthesis, Xanthenes radiation effects, Chlorambucil analogs & derivatives, Chlorambucil pharmacology, Prodrugs pharmacology, Umbelliferones pharmacology, Xanthenes pharmacology
Abstract

A FRET donor-acceptor xanthene-coumarin conjugate has been designed for redox-regulated synergic treatment of photodynamic therapy and chemotherapy with real-time monitoring. The "locked" FRET pair was selectively "unlocked" by biological reducing thiols via rupture of a sacrificial disulfide linker. A distinct change in fluorescence color and selective cancer cell toxicity were observed in vitro.

Published
2017
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results